Asymmetric 1,4-functionalization of 1,3-enynes via dual photoredox and chromium catalysis

Feng-Hua Zhang; Xiaochong Guo; Xianrong Zeng; Zhaobin Wang

doi:10.1038/s41467-022-32614-4

Nature Communications (Aug 2022)

Asymmetric 1,4-functionalization of 1,3-enynes via dual photoredox and chromium catalysis

Feng-Hua Zhang,
Xiaochong Guo,
Xianrong Zeng,
Zhaobin Wang

Affiliations

Feng-Hua Zhang: Key Laboratory of Precise Synthesis of Functional Molecules of Zhejiang Province, Department of Chemistry, School of Science, Westlake University
Xiaochong Guo: Key Laboratory of Precise Synthesis of Functional Molecules of Zhejiang Province, Department of Chemistry, School of Science, Westlake University
Xianrong Zeng: Key Laboratory of Precise Synthesis of Functional Molecules of Zhejiang Province, Department of Chemistry, School of Science, Westlake University
Zhaobin Wang: Key Laboratory of Precise Synthesis of Functional Molecules of Zhejiang Province, Department of Chemistry, School of Science, Westlake University

DOI: https://doi.org/10.1038/s41467-022-32614-4
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 11

Abstract

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In contrast to the better-studied ionic pathway, radical-involved asymmetric 1,4-functionalization of 1,3-enynes remains a prominent challenge. Here, the authors describe the asymmetric three-component 1,4-dialkylation of 1,3-enynes via dual photoredox and chromium catalysis to provide chiral allenols.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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