Study on Cell-Capturing Microfluidic Device in High Flow Rates through Controlling Shape of Microstructures and Their Alignments

Abstract

A new cell-trapping method for single cell analysis devices at a very rapid flow rate, is designed, fabricated and characterized by controlling shapes of microstructures and their arrangements in array just simply and effectively within the microfluidic channels. We simulated using a commercialized computational fluidic dynamic simulator (CFD-ACE+) and demonstrated experimentally that the cell-capturing rate enhanced over three times and a high capturing efficiency of about 70% at a 300 µL/min at the cross-arranged left-turned isosceles trapezoid. The device is applicable for a tool in the field of characterization of rare cells, personal medicine, and prognostic of disease.

Keywords

• microfluidic device
• rare cell capturing
• shape control
• high flow rate