Systemic Inflammatory Response in Unilateral Sinonasal Polyps

Abstract

Introduction:Sinonasal polypoid disease is an inflammatory condition that can be unilateral. Various inflammatory markers have been used for evaluating systemic inflammatory response to diseases. This study aimed to evaluate systemic inflammatory markers in unilateral sinonasal polyps, to compare antrochoanal polyps and unilateral sinonasal polyposis in means of a systemic inflammatory reaction, and to assess systemic inflammatory reflection of involvement grade of paranasal sinuses.Methods:Eighty-five patients were retrospectively analyzed and were divided into two groups as antrochoanal polyp group (APG) and unilateral polyposis group (UPG). Twenty patients who underwent septoplasty operation were taken as control septoplasty group (CSG). Preoperative neutrophil (Neu %), lymphocyte (Lym %) and eosinophil percentages (Eos %), thrombocyte counts (Plt), red cell distribution width (RDW), neutrophil to lymphocyte ratio, eosinophil to lymphocyte ratio (ELR), and extent of polyps in paranasal sinus computed tomography (PNS-CT) were recorded.Results:Total polyp grade in PNS-CT of UPG was higher than APG (p0.05). RDW in CSG was lower than APG and UPG (p0.05).Conclusion:Extent of unilateral sinonasal polypoid disease does not affect the severity of systemic inflammation. The effects of antrochoanal polyps on systemic inflammation are similar to the effects of unilateral sinonasal polyps.

Keywords

• chronic rhinosinusitis with nasal polyp
• systemic inflammation
• antrochoanal polyp
• nasal polyp
• neutrophil to eosinophil ratio
• red cell distribution width