Nature Communications (Feb 2021)

Inference and analysis of cell-cell communication using CellChat

  • Suoqin Jin,
  • Christian F. Guerrero-Juarez,
  • Lihua Zhang,
  • Ivan Chang,
  • Raul Ramos,
  • Chen-Hsiang Kuan,
  • Peggy Myung,
  • Maksim V. Plikus,
  • Qing Nie

DOI
https://doi.org/10.1038/s41467-021-21246-9
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 20

Abstract

Read online

Single-cell methods record molecule expressions of cells in a given tissue, but understanding interactions between cells remains challenging. Here the authors show by applying systems biology and machine learning approaches that they can infer and analyze cell-cell communication networks in an easily interpretable way.