In vivo modulation of endothelial polarization by Apelin receptor signalling

Hyouk-Bum Kwon; Shengpeng Wang; Christian S. M. Helker; S. Javad Rasouli; Hans-Martin Maischein; Stefan Offermanns; Wiebke Herzog; Didier Y. R. Stainier

doi:10.1038/ncomms11805

Nature Communications (Jun 2016)

In vivo modulation of endothelial polarization by Apelin receptor signalling

Hyouk-Bum Kwon,
Shengpeng Wang,
Christian S. M. Helker,
S. Javad Rasouli,
Hans-Martin Maischein,
Stefan Offermanns,
Wiebke Herzog,
Didier Y. R. Stainier

Affiliations

Hyouk-Bum Kwon: Department of Developmental Genetics, Max Planck Institute for Heart and Lung Research
Shengpeng Wang: Department of Pharmacology, Max Planck Institute for Heart and Lung Research
Christian S. M. Helker: Department of Developmental Genetics, Max Planck Institute for Heart and Lung Research
S. Javad Rasouli: Department of Developmental Genetics, Max Planck Institute for Heart and Lung Research
Hans-Martin Maischein: Department of Developmental Genetics, Max Planck Institute for Heart and Lung Research
Stefan Offermanns: Department of Pharmacology, Max Planck Institute for Heart and Lung Research
Wiebke Herzog: University of Münster
Didier Y. R. Stainier: Department of Developmental Genetics, Max Planck Institute for Heart and Lung Research

DOI: https://doi.org/10.1038/ncomms11805
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 12

Abstract

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Endothelial cells align in the direction of flow in response to shear stress. Here the authors describe a zebrafish model for visualization of endothelial polarization and demonstrate that endothelial cell alignment depends on blood flow and Apelin signalling.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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