Namık Kemal Tıp Dergisi (Dec 2019)
The Relation Between Dipper, Non-dipper Hypertension and Uric Acid Level and Clearance in Newly Diagnosed Hypertensive Patients
Abstract
Aim:While there are some studies reporting that higher levels of uric acid (UA) has an effect on the development of hypertension (HT), the relation between dipper, non-dipper HT and hyperuricemia and UA clearance is not clear. In our study; We aimed to evaluate the relationship between dipper, non-dipper HT and UA level and clearance in newly diagnosed HT patients.Materials and Methods:59 patients with diagnosed HT and 24 healthy individuals who were followed-up in departments of Internal Medicine and Nephrology, were included into the study. UA clearance and sodium in 24 hour urine were analyzed. Office blood pressure (BP) and 24-hour ambulatory blood pressure (24-h ABPM) were measured. Blood sample was obtained for biochemical analysis.Results:59 newly diagnosed HT patients and 24 healthy individuals were included into the study. The correlation analysis of the hypertensive patient group revealed a positive correlation between the UA and creatinine levels (r = 0.509) (p <0.01) and a negative correlation between UA level and UA clearance (r = - 0.494) (p <0.01). Non-dipper cases consisted of 44.1% of the HT patients. There was no statistically significant difference among the demographic and laboratory parameters between dipper and nondipper patients.Conclusion:In this study where UA level and clearance in dipper, non-dipper hypertensive cases of newly diagnosed hypertension are evaluated; UA clearance was found to be positively correlated with higher BP where as the level of UA was not significantly elevated in hypertension cases and non-dipper hypertension patients.
