Frontiers in Immunology (Feb 2025)

KLF4: a multifunctional nexus connecting tumor progression and immune regulation

  • Yunjie Ju,
  • Wen Xiao,
  • Bryan James Mathis,
  • Ying Shi

DOI
https://doi.org/10.3389/fimmu.2025.1514780
Journal volume & issue
Vol. 16

Abstract

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Krüppel-like factors (KLFs) regulate various biological processes such as cell proliferation, migration, invasion, and differentiation as gene transcription factors. Signaling pathways which mediated by KLF4 and KLF4 have a sophisticated role in tumors due to multiple factors, including the types or stage of tumors. KLF4 plays a promoter role in tumorigenesis and development, or tumor suppressor as a context-dependent anti- and pro-inflammatory factor. KLF4 over-expression increases CD8+T cell differentiation and enhances the antitumor immunity. This review aims to provide information about the relationship of KLF4 in immunity with tumors and to guide the future study.

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