Nature Communications (Jan 2016)
Novel role for anti-Müllerian hormone in the regulation of GnRH neuron excitability and hormone secretion
- Irene Cimino,
- Filippo Casoni,
- Xinhuai Liu,
- Andrea Messina,
- Jyoti Parkash,
- Soazik P. Jamin,
- Sophie Catteau-Jonard,
- Francis Collier,
- Marc Baroncini,
- Didier Dewailly,
- Pascal Pigny,
- Mel Prescott,
- Rebecca Campbell,
- Allan E. Herbison,
- Vincent Prevot,
- Paolo Giacobini
Affiliations
- Irene Cimino
- Inserm, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Jean-Pierre Aubert Research Centre, U1172
- Filippo Casoni
- Inserm, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Jean-Pierre Aubert Research Centre, U1172
- Xinhuai Liu
- Centre for Neuroendocrinology and Department of Physiology, University of Otago School of Medical Sciences
- Andrea Messina
- Inserm, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Jean-Pierre Aubert Research Centre, U1172
- Jyoti Parkash
- Inserm, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Jean-Pierre Aubert Research Centre, U1172
- Soazik P. Jamin
- Inserm U1085-IRSET, Université de Rennes 1
- Sophie Catteau-Jonard
- Inserm, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Jean-Pierre Aubert Research Centre, U1172
- Francis Collier
- University of Lille, FHU 1,000 Days for Health, School of Medicine and SFR DN2M
- Marc Baroncini
- Inserm, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Jean-Pierre Aubert Research Centre, U1172
- Didier Dewailly
- Inserm, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Jean-Pierre Aubert Research Centre, U1172
- Pascal Pigny
- University of Lille, FHU 1,000 Days for Health, School of Medicine and SFR DN2M
- Mel Prescott
- Centre for Neuroendocrinology and Department of Physiology, University of Otago School of Medical Sciences
- Rebecca Campbell
- Centre for Neuroendocrinology and Department of Physiology, University of Otago School of Medical Sciences
- Allan E. Herbison
- Centre for Neuroendocrinology and Department of Physiology, University of Otago School of Medical Sciences
- Vincent Prevot
- Inserm, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Jean-Pierre Aubert Research Centre, U1172
- Paolo Giacobini
- Inserm, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Jean-Pierre Aubert Research Centre, U1172
- DOI
- https://doi.org/10.1038/ncomms10055
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 12
Abstract
Anti-Müllerian hormone (AMH) plays a role in sexual differentiation and gonadal function, but extra-gonadal effects of AMH are not known. Here Cimino et al. show that AMH activates a subset of gonadotrophin-releasing hormone (GnRH)-releasing neurons, contributing to luteinizing hormone secretion from the pituitary gland.
