Nature Communications (Jul 2018)
Recurrent homozygous deletion of DROSHA and microduplication of PDE4DIP in pineoblastoma
- Matija Snuderl,
- Kasthuri Kannan,
- Elke Pfaff,
- Shiyang Wang,
- James M. Stafford,
- Jonathan Serrano,
- Adriana Heguy,
- Karina Ray,
- Arline Faustin,
- Olga Aminova,
- Igor Dolgalev,
- Stacie L. Stapleton,
- David Zagzag,
- Luis Chiriboga,
- Sharon L. Gardner,
- Jeffrey H. Wisoff,
- John G. Golfinos,
- David Capper,
- Volker Hovestadt,
- Marc K. Rosenblum,
- Dimitris G. Placantonakis,
- Sarah E. LeBoeuf,
- Thales Y. Papagiannakopoulos,
- Lukas Chavez,
- Sama Ahsan,
- Charles G. Eberhart,
- Stefan M. Pfister,
- David T. W. Jones,
- Matthias A. Karajannis
Affiliations
- Matija Snuderl
- Division of Neuropathology, NYU Langone Health
- Kasthuri Kannan
- Division of Neuropathology, NYU Langone Health
- Elke Pfaff
- Hopp Children’s Cancer Center at the NCT Heidelberg (KiTZ)
- Shiyang Wang
- Division of Pediatric Hematology/Oncology, NYU Langone Health
- James M. Stafford
- Department of Biochemistry and Molecular Pharmacology, NYU Langone Health
- Jonathan Serrano
- Genome Technology Center, NYU Langone Health
- Adriana Heguy
- Laura and Isaac Perlmutter Cancer Center, NYU Langone Health
- Karina Ray
- Genome Technology Center, NYU Langone Health
- Arline Faustin
- Department of Neurology, NYU Langone Health
- Olga Aminova
- Genome Technology Center, NYU Langone Health
- Igor Dolgalev
- Department of Pathology, NYU Langone Health
- Stacie L. Stapleton
- Johns Hopkins All Children’s Hospital, Cancer and Blood Disorders Institute
- David Zagzag
- Division of Neuropathology, NYU Langone Health
- Luis Chiriboga
- Department of Pathology, NYU Langone Health
- Sharon L. Gardner
- Laura and Isaac Perlmutter Cancer Center, NYU Langone Health
- Jeffrey H. Wisoff
- Department of Neurosurgery, NYU Langone Health
- John G. Golfinos
- Department of Neurosurgery, NYU Langone Health
- David Capper
- Department of Neuropathology, Institute of Pathology, University of Heidelberg
- Volker Hovestadt
- Division of Molecular Genetics, German Cancer Research Center (DKFZ)
- Marc K. Rosenblum
- Department of Pathology, Memorial Sloan Kettering Cancer Center
- Dimitris G. Placantonakis
- Johns Hopkins All Children’s Hospital, Cancer and Blood Disorders Institute
- Sarah E. LeBoeuf
- Department of Pathology, NYU Langone Health
- Thales Y. Papagiannakopoulos
- Department of Pathology, NYU Langone Health
- Lukas Chavez
- Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ)
- Sama Ahsan
- Division of Pediatric Oncology, Johns Hopkins Hospital
- Charles G. Eberhart
- Department of Pathology, Johns Hopkins Hospital
- Stefan M. Pfister
- Hopp Children’s Cancer Center at the NCT Heidelberg (KiTZ)
- David T. W. Jones
- Hopp Children’s Cancer Center at the NCT Heidelberg (KiTZ)
- Matthias A. Karajannis
- Department of Pediatrics, Memorial Sloan Kettering Cancer Center
- DOI
- https://doi.org/10.1038/s41467-018-05029-3
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 10
Abstract
Pineoblastoma is a highly aggressive and rare childhood brain cancer, and the genetic drivers of sporadic pineoblastoma are unknown. Here, the authors genomically interrogated pediatric and adult pineoblastomas and found novel variants including recurrent homozygous deletions of DROSHA.
