Nature Communications (Jul 2018)
Intermedin protects against sepsis by concurrently re-establishing the endothelial barrier and alleviating inflammatory responses
- Fei Xiao,
- Denian Wang,
- Lingmiao Kong,
- Min Li,
- Zhongxue Feng,
- Bingxing Shuai,
- Lijun Wang,
- Yong’gang Wei,
- Hongyu Li,
- Sisi Wu,
- Chun Tan,
- Huan Zhao,
- Xuejiao Hu,
- Jin Liu,
- Yan Kang,
- Xuelian Liao,
- Yan Zhou,
- Wei Zhang
Affiliations
- Fei Xiao
- Molecular Medicine Research Center, State Key Laboratory of Biotherapy/Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University
- Denian Wang
- Molecular Medicine Research Center, State Key Laboratory of Biotherapy/Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University
- Lingmiao Kong
- Molecular Medicine Research Center, State Key Laboratory of Biotherapy/Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University
- Min Li
- Molecular Medicine Research Center, State Key Laboratory of Biotherapy/Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University
- Zhongxue Feng
- Molecular Medicine Research Center, State Key Laboratory of Biotherapy/Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University
- Bingxing Shuai
- Department of Intensive Care Unit, West China Hospital, Sichuan University
- Lijun Wang
- Molecular Medicine Research Center, State Key Laboratory of Biotherapy/Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University
- Yong’gang Wei
- Department of Liver Surgery, West China Hospital, Sichuan University
- Hongyu Li
- Department of Liver Surgery, West China Hospital, Sichuan University
- Sisi Wu
- Molecular Medicine Research Center, State Key Laboratory of Biotherapy/Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University
- Chun Tan
- Molecular Medicine Research Center, State Key Laboratory of Biotherapy/Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University
- Huan Zhao
- Molecular Medicine Research Center, State Key Laboratory of Biotherapy/Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University
- Xuejiao Hu
- Department of Laboratory Medicine, West China Hospital, Sichuan University
- Jin Liu
- Department of Anesthesiology, West China Hospital, Sichuan University
- Yan Kang
- Department of Intensive Care Unit, West China Hospital, Sichuan University
- Xuelian Liao
- Department of Intensive Care Unit, West China Hospital, Sichuan University
- Yan Zhou
- Department of Intensive Care Unit, West China Hospital, Sichuan University
- Wei Zhang
- Molecular Medicine Research Center, State Key Laboratory of Biotherapy/Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University
- DOI
- https://doi.org/10.1038/s41467-018-05062-2
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 15
Abstract
Sepsis is a life-threatening condition. Here, the authors show that intermedin alleviates organ injury and decreases mortality in septic mice by concurrently alleviating vascular leakage and inflammatory responses. Patients with high intermedin levels exhibit a low risk of shock, lower severity scores, and greatly improved survival outcomes.
