Communications Biology (Nov 2021)
Long-read metagenomics of soil communities reveals phylum-specific secondary metabolite dynamics
- Marc W. Van Goethem,
- Andrew R. Osborn,
- Benjamin P. Bowen,
- Peter F. Andeer,
- Tami L. Swenson,
- Alicia Clum,
- Robert Riley,
- Guifen He,
- Maxim Koriabine,
- Laura Sandor,
- Mi Yan,
- Chris G. Daum,
- Yuko Yoshinaga,
- Thulani P. Makhalanyane,
- Ferran Garcia-Pichel,
- Axel Visel,
- Len A. Pennacchio,
- Ronan C. O’Malley,
- Trent R. Northen
Affiliations
- Marc W. Van Goethem
- Environmental Genomics and Systems Biology, Lawrence Berkeley National Laboratory
- Andrew R. Osborn
- DOE Joint Genome Institute, Lawrence Berkeley National Laboratory
- Benjamin P. Bowen
- Environmental Genomics and Systems Biology, Lawrence Berkeley National Laboratory
- Peter F. Andeer
- Environmental Genomics and Systems Biology, Lawrence Berkeley National Laboratory
- Tami L. Swenson
- Environmental Genomics and Systems Biology, Lawrence Berkeley National Laboratory
- Alicia Clum
- DOE Joint Genome Institute, Lawrence Berkeley National Laboratory
- Robert Riley
- DOE Joint Genome Institute, Lawrence Berkeley National Laboratory
- Guifen He
- DOE Joint Genome Institute, Lawrence Berkeley National Laboratory
- Maxim Koriabine
- DOE Joint Genome Institute, Lawrence Berkeley National Laboratory
- Laura Sandor
- DOE Joint Genome Institute, Lawrence Berkeley National Laboratory
- Mi Yan
- DOE Joint Genome Institute, Lawrence Berkeley National Laboratory
- Chris G. Daum
- DOE Joint Genome Institute, Lawrence Berkeley National Laboratory
- Yuko Yoshinaga
- DOE Joint Genome Institute, Lawrence Berkeley National Laboratory
- Thulani P. Makhalanyane
- Centre for Microbial Ecology and Genomics, Department of Biochemistry, Genomics and Microbiology, University of Pretoria
- Ferran Garcia-Pichel
- Center for Fundamental and Applied Microbiomics, Biodesign Institute, Arizona State University
- Axel Visel
- DOE Joint Genome Institute, Lawrence Berkeley National Laboratory
- Len A. Pennacchio
- DOE Joint Genome Institute, Lawrence Berkeley National Laboratory
- Ronan C. O’Malley
- Environmental Genomics and Systems Biology, Lawrence Berkeley National Laboratory
- Trent R. Northen
- Environmental Genomics and Systems Biology, Lawrence Berkeley National Laboratory
- DOI
- https://doi.org/10.1038/s42003-021-02809-4
- Journal volume & issue
-
Vol. 4,
no. 1
pp. 1 – 10
Abstract
Marc Van Goethem et al. combine short- and long-read sequencing from biocrust samples to report nearly 3,000 biosynthetic gene clusters (BGCs) encoding microbial secondary metabolites. Their results demonstrate the advantage of integrated metatranscriptomic and long-read metagenomic sequencing in analyzing BGCs and provides insight into the role of secondary metabolites in maintaining phylogenetic niches in biocrusts.
