NeuroImage: Clinical (Jan 2020)
Reduced fronto-striatal volume in attention-deficit/hyperactivity disorder in two cohorts across the lifespan
- Renata Basso Cupertino,
- Sourena Soheili-Nezhad,
- Eugenio Horacio Grevet,
- Cibele Edom Bandeira,
- Felipe Almeida Picon,
- Maria Eduarda de Araujo Tavares,
- Jilly Naaijen,
- Daan van Rooij,
- Sophie Akkermans,
- Eduardo Schneider Vitola,
- Marcel P Zwiers,
- Diego Luiz Rovaris,
- Pieter J. Hoekstra,
- Vitor Breda,
- Jaap Oosterlaan,
- Catharina A Hartman,
- Christian F Beckmann,
- Jan K Buitelaar,
- Barbara Franke,
- Claiton Henrique Dotto Bau,
- Emma Sprooten
Affiliations
- Renata Basso Cupertino
- Department of Psychiatry, University of Vermont, Burlington, VT, USA
- Sourena Soheili-Nezhad
- Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, Radboud University Medical Center, Nijmegen, The Netherlands; Centre for Cognitive Neuroimaging, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, Radboud University Medical Center, Nijmegen, The Netherlands
- Eugenio Horacio Grevet
- Department of Psychiatry, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil; Adulthood ADHD Outpatient Program (ProDAH), Clinical Research Center, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil; Developmental Psychiatry Program, Experimental Research Center, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil
- Cibele Edom Bandeira
- Adulthood ADHD Outpatient Program (ProDAH), Clinical Research Center, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil; Developmental Psychiatry Program, Experimental Research Center, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil; Department of Genetics, Instituto de Biociências, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
- Felipe Almeida Picon
- Adulthood ADHD Outpatient Program (ProDAH), Clinical Research Center, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil; Developmental Psychiatry Program, Experimental Research Center, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil
- Maria Eduarda de Araujo Tavares
- Adulthood ADHD Outpatient Program (ProDAH), Clinical Research Center, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil; Developmental Psychiatry Program, Experimental Research Center, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil; Department of Genetics, Instituto de Biociências, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
- Jilly Naaijen
- Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, Radboud University Medical Center, Nijmegen, The Netherlands; Centre for Cognitive Neuroimaging, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, Radboud University Medical Center, Nijmegen, The Netherlands
- Daan van Rooij
- Centre for Cognitive Neuroimaging, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, Radboud University Medical Center, Nijmegen, The Netherlands
- Sophie Akkermans
- Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, Radboud University Medical Center, Nijmegen, The Netherlands; Centre for Cognitive Neuroimaging, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, Radboud University Medical Center, Nijmegen, The Netherlands
- Eduardo Schneider Vitola
- Adulthood ADHD Outpatient Program (ProDAH), Clinical Research Center, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil; Developmental Psychiatry Program, Experimental Research Center, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil
- Marcel P Zwiers
- Centre for Cognitive Neuroimaging, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, Radboud University Medical Center, Nijmegen, The Netherlands
- Diego Luiz Rovaris
- Universidade de Sao Paulo Instituto de Ciencias Biomedicas Departamento de Fisiologia e Biofisica, São Paulo, Brazil
- Pieter J. Hoekstra
- University of Groningen, University Medical Center Groningen, Department of Psychiatry, Groningen, The Netherlands
- Vitor Breda
- Adulthood ADHD Outpatient Program (ProDAH), Clinical Research Center, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil; Developmental Psychiatry Program, Experimental Research Center, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil
- Jaap Oosterlaan
- Emma Children’s Hospital, Amsterdam UMC, University of Amsterdam, Emma Neuroscience Group, Department of Pediatrics, Amsterdam Reproduction & Development, Amsterdam, The Netherlands; Vrije Universiteit, Clinical Neuropsychology Section, Van der Boechortstraat 7, 1081 BT Amsterdam, The Netherlands
- Catharina A Hartman
- Emma Children’s Hospital, Amsterdam UMC, University of Amsterdam, Emma Neuroscience Group, Department of Pediatrics, Amsterdam Reproduction & Development, Amsterdam, The Netherlands; Vrije Universiteit, Clinical Neuropsychology Section, Van der Boechortstraat 7, 1081 BT Amsterdam, The Netherlands
- Christian F Beckmann
- Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, Radboud University Medical Center, Nijmegen, The Netherlands; Centre for Cognitive Neuroimaging, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, Radboud University Medical Center, Nijmegen, The Netherlands
- Jan K Buitelaar
- Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, Radboud University Medical Center, Nijmegen, The Netherlands; Karakter Child and Adolescent Psychiatry University Centre, Nijmegen, The Netherlands
- Barbara Franke
- Department of Human Genetics, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands; Department of Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands
- Claiton Henrique Dotto Bau
- Adulthood ADHD Outpatient Program (ProDAH), Clinical Research Center, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil; Developmental Psychiatry Program, Experimental Research Center, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil; Department of Genetics, Instituto de Biociências, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil; Corresponding authors at: Department of Genetics, Instituto de Biociências, UFRGS, Avenida Bento Gonçalves, 9500 Porto Alegre RS91501-970, Brazil (C.H.D. Bau). Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, Radboud University Medical Center, Kapittelweg 29 – Nijmegen 6525, The Netherlands (E. Sprooten).
- Emma Sprooten
- Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, Radboud University Medical Center, Nijmegen, The Netherlands; Centre for Cognitive Neuroimaging, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, Radboud University Medical Center, Nijmegen, The Netherlands; Corresponding authors at: Department of Genetics, Instituto de Biociências, UFRGS, Avenida Bento Gonçalves, 9500 Porto Alegre RS91501-970, Brazil (C.H.D. Bau). Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, Radboud University Medical Center, Kapittelweg 29 – Nijmegen 6525, The Netherlands (E. Sprooten).
- Journal volume & issue
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Vol. 28
p. 102403
Abstract
Attention-Deficit/Hyperactivity Disorder (ADHD) has been associated with altered brain anatomy in neuroimaging studies. However, small and heterogeneous study samples, and the use of region-of-interest and tissue-specific analyses have limited the consistency and replicability of these effects. We used a data-driven multivariate approach to investigate neuroanatomical features associated with ADHD in two independent cohorts: the Dutch NeuroIMAGE cohort (n = 890, 17.2 years) and the Brazilian IMpACT cohort (n = 180, 44.2 years). Using independent component analysis of whole-brain morphometry images, 375 neuroanatomical components were assessed for association with ADHD. In both discovery (corrected-p = 0.0085) and replication (p = 0.032) cohorts, ADHD was associated with reduced volume in frontal lobes, striatum, and their interconnecting white-matter. Current results provide further evidence for the role of the fronto-striatal circuit in ADHD in children, and for the first time show its relevance to ADHD in adults. The fact that the cohorts are from different continents and comprise different age ranges highlights the robustness of the findings.
