Nature Communications (Nov 2021)

Aptamer-assisted tumor localization of bacteria for enhanced biotherapy

  • Zhongmin Geng,
  • Zhenping Cao,
  • Rui Liu,
  • Ke Liu,
  • Jinyao Liu,
  • Weihong Tan

DOI
https://doi.org/10.1038/s41467-021-26956-8
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 12

Abstract

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Bacteria-based therapy has shown promise for cancer treatment. To enhance tumor accumulation, here the authors describe the design of tumor specific aptamer-conjugated bacteria, to improve intratumor localization and enhance therapeutic efficacy.