Nature Communications (Oct 2016)

Elucidation of the biosynthesis of carnosic acid and its reconstitution in yeast

  • Ulschan Scheler,
  • Wolfgang Brandt,
  • Andrea Porzel,
  • Kathleen Rothe,
  • David Manzano,
  • Dragana Božić,
  • Dimitra Papaefthimiou,
  • Gerd Ulrich Balcke,
  • Anja Henning,
  • Swanhild Lohse,
  • Sylvestre Marillonnet,
  • Angelos K. Kanellis,
  • Albert Ferrer,
  • Alain Tissier

DOI
https://doi.org/10.1038/ncomms12942
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 11

Abstract

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Diterpenes are plant products with high antioxidant properties and potential application as food additives and therapeutics. Here, the authors describe the complete biosynthetic pathway of carnosic acid and reconstruct it in yeast, opening the way to metabolic engineering of phenolic diterpenes.