Frontiers in Chemistry (Nov 2018)
Engineered Nanostructured Materials for Ofloxacin Delivery
- Silvia Nuti,
- Silvia Nuti,
- Javier Fernández-Lodeiro,
- Javier Fernández-Lodeiro,
- Benedetta Del Secco,
- Enrico Rampazzo,
- Benito Rodríguez-González,
- José L. Capelo,
- José L. Capelo,
- Vanessa Silva,
- Vanessa Silva,
- Vanessa Silva,
- Vanessa Silva,
- Gilberto Igrejas,
- Gilberto Igrejas,
- Gilberto Igrejas,
- Patrícia Poeta,
- Patrícia Poeta,
- Cármen Torres,
- Nelsi Zaccheroni,
- Luca Prodi,
- Elisabete Oliveira,
- Elisabete Oliveira,
- Carlos Lodeiro,
- Carlos Lodeiro
Affiliations
- Silvia Nuti
- BIOSCOPE Group, LAQV@REQUIMTE, Chemistry Department, Faculty of Science and Technology, NOVA University of Lisbon, Almada, Portugal
- Silvia Nuti
- G. Ciamician Department of Chemistry, University of Bologna, Bologna, Italy
- Javier Fernández-Lodeiro
- BIOSCOPE Group, LAQV@REQUIMTE, Chemistry Department, Faculty of Science and Technology, NOVA University of Lisbon, Almada, Portugal
- Javier Fernández-Lodeiro
- Proteomass Scientific Society, Costa de Caparica, Portugal
- Benedetta Del Secco
- G. Ciamician Department of Chemistry, University of Bologna, Bologna, Italy
- Enrico Rampazzo
- G. Ciamician Department of Chemistry, University of Bologna, Bologna, Italy
- Benito Rodríguez-González
- Scientific and Technological Research Assistance Centre (CACTI), University of Vigo, Vigo, Spain
- José L. Capelo
- BIOSCOPE Group, LAQV@REQUIMTE, Chemistry Department, Faculty of Science and Technology, NOVA University of Lisbon, Almada, Portugal
- José L. Capelo
- Proteomass Scientific Society, Costa de Caparica, Portugal
- Vanessa Silva
- Department of Genetics and Biotechnology, University of Trás-os-Montes and Alto Douro, Vila Real, Portugal
- Vanessa Silva
- Functional Genomics and Proteomics Unit, University of Trás-os-Montes and Alto Douro, Vila Real, Portugal
- Vanessa Silva
- Veterinary Science Department, University of Trás-os-Montes and Alto Douro, Vila Real, Portugal
- Vanessa Silva
- LAQV-REQUIMTE, Faculty of Science and Technology, Nova University of Lisbon, Lisbon, Portugal
- Gilberto Igrejas
- Department of Genetics and Biotechnology, University of Trás-os-Montes and Alto Douro, Vila Real, Portugal
- Gilberto Igrejas
- Functional Genomics and Proteomics Unit, University of Trás-os-Montes and Alto Douro, Vila Real, Portugal
- Gilberto Igrejas
- LAQV-REQUIMTE, Faculty of Science and Technology, Nova University of Lisbon, Lisbon, Portugal
- Patrícia Poeta
- Veterinary Science Department, University of Trás-os-Montes and Alto Douro, Vila Real, Portugal
- Patrícia Poeta
- LAQV-REQUIMTE, Faculty of Science and Technology, Nova University of Lisbon, Lisbon, Portugal
- Cármen Torres
- Área de Bioquímica y Biología Molecular, Universidad de La Rioja, Logroño, Spain
- Nelsi Zaccheroni
- G. Ciamician Department of Chemistry, University of Bologna, Bologna, Italy
- Luca Prodi
- G. Ciamician Department of Chemistry, University of Bologna, Bologna, Italy
- Elisabete Oliveira
- BIOSCOPE Group, LAQV@REQUIMTE, Chemistry Department, Faculty of Science and Technology, NOVA University of Lisbon, Almada, Portugal
- Elisabete Oliveira
- Proteomass Scientific Society, Costa de Caparica, Portugal
- Carlos Lodeiro
- BIOSCOPE Group, LAQV@REQUIMTE, Chemistry Department, Faculty of Science and Technology, NOVA University of Lisbon, Almada, Portugal
- Carlos Lodeiro
- Proteomass Scientific Society, Costa de Caparica, Portugal
- DOI
- https://doi.org/10.3389/fchem.2018.00554
- Journal volume & issue
-
Vol. 6
Abstract
Antibiotic resistance is emerging as a growing worldwide problem and finding solutions to this issue is becoming a new challenge for scientists. As the development of new drugs slowed down, advances in nanotechnology offer great opportunities, with the possibility of designing new systems for carrying, delivery and administration of drugs already in use. Engineered combinations of the synthetic, broad-spectrum antibiotic ofloxacin, rarely studied in this field, with different types of silver, mesoporous silica-based and Pluronic/silica-based nanoparticles have been explored. The nanocarriers as silver core@silica mesoporous (AgMSNPs) and dye-doped silica nanoparticles functionalized with ofloxacin were synthesized and their antibacterial properties studied against S. aureus and E. coli. The best antibacterial results were obtained for the AgMSNPs nanosystem@ofloxacin for the strain S. aureus ATCC 25923, with MIC and MBC values of 5 and 25 μg/mL, proving the efficacy and synergetic effect of the antibiotic and the Ag core of the nanoparticles.
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