Maintenance of cell type-specific connectivity and circuit function requires Tao kinase

Federico Marcello Tenedini; Maria Sáez González; Chun Hu; Lisa Hedegaard Pedersen; Mabel Matamala Petruzzi; Bettina Spitzweck; Denan Wang; Melanie Richter; Meike Petersen; Emanuela Szpotowicz; Michaela Schweizer; Stephan J. Sigrist; Froylan Calderon de Anda; Peter Soba

doi:10.1038/s41467-019-11408-1

Nature Communications (Aug 2019)

Maintenance of cell type-specific connectivity and circuit function requires Tao kinase

Federico Marcello Tenedini,
Maria Sáez González,
Chun Hu,
Lisa Hedegaard Pedersen,
Mabel Matamala Petruzzi,
Bettina Spitzweck,
Denan Wang,
Melanie Richter,
Meike Petersen,
Emanuela Szpotowicz,
Michaela Schweizer,
Stephan J. Sigrist,
Froylan Calderon de Anda,
Peter Soba

Affiliations

Federico Marcello Tenedini: Neuronal Patterning and Connectivity laboratory, Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf
Maria Sáez González: Neuronal Patterning and Connectivity laboratory, Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf
Chun Hu: Neuronal Patterning and Connectivity laboratory, Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf
Lisa Hedegaard Pedersen: Neuronal Patterning and Connectivity laboratory, Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf
Mabel Matamala Petruzzi: Neuronal Patterning and Connectivity laboratory, Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf
Bettina Spitzweck: Neuronal Patterning and Connectivity laboratory, Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf
Denan Wang: Neuronal Patterning and Connectivity laboratory, Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf
Melanie Richter: Neuronal Development laboratory, Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf
Meike Petersen: Neuronal Patterning and Connectivity laboratory, Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf
Emanuela Szpotowicz: Electron microscopy unit, Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf
Michaela Schweizer: Electron microscopy unit, Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf
Stephan J. Sigrist: Institute of Biology, Free University Berlin
Froylan Calderon de Anda: Neuronal Development laboratory, Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf
Peter Soba: Neuronal Patterning and Connectivity laboratory, Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf

DOI: https://doi.org/10.1038/s41467-019-11408-1
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 16

Abstract

Read online

It is unclear how circuit specificity and function are maintained during organismal growth. In this study, authors show that connectivity between primary nociceptors and their downstream neurons scales with animal size and that Ste20-like kinase Tao acts as a negative regulator of synaptic growth required for maintenance of circuit specificity and connectivity.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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