Chromatin remodeller SMARCA4 recruits topoisomerase 1 and suppresses transcription-associated genomic instability

Afzal Husain; Nasim A. Begum; Takako Taniguchi; Hisaaki Taniguchi; Maki Kobayashi; Tasuku Honjo

doi:10.1038/ncomms10549

Nature Communications (Feb 2016)

Chromatin remodeller SMARCA4 recruits topoisomerase 1 and suppresses transcription-associated genomic instability

Afzal Husain,
Nasim A. Begum,
Takako Taniguchi,
Hisaaki Taniguchi,
Maki Kobayashi,
Tasuku Honjo

Affiliations

Afzal Husain: Department of Immunology and Genomic Medicine, Graduate School of Medicine, Kyoto University, Yoshida-Konoe cho, Sakyo-ku
Nasim A. Begum: Department of Immunology and Genomic Medicine, Graduate School of Medicine, Kyoto University, Yoshida-Konoe cho, Sakyo-ku
Takako Taniguchi: Division of Disease Proteomics, Institute for Enzyme Research, University of Tokushima
Hisaaki Taniguchi: Division of Disease Proteomics, Institute for Enzyme Research, University of Tokushima
Maki Kobayashi: Department of Immunology and Genomic Medicine, Graduate School of Medicine, Kyoto University, Yoshida-Konoe cho, Sakyo-ku
Tasuku Honjo: Department of Immunology and Genomic Medicine, Graduate School of Medicine, Kyoto University, Yoshida-Konoe cho, Sakyo-ku

DOI: https://doi.org/10.1038/ncomms10549
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 15

Abstract

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Topoisomerase 1 (TOP1) relieves superhelical tension when DNA strands are unwound during transcription. Here, Husain et al. report that SMARCA4, an ATP-dependent chromatin remodeller, is associated with TOP1 and suppresses transcription-associated genomic instability.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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