Relationship between body fat ratio and inflammatory markers in a Chinese population of adult male smokers

Xiu Zang; Xiangyu Meng; Xuekui Liu; Houfa Geng; Jun Liang

Preventive Medicine Reports (Dec 2023)

Relationship between body fat ratio and inflammatory markers in a Chinese population of adult male smokers

Xiu Zang,
Xiangyu Meng,
Xuekui Liu,
Houfa Geng,
Jun Liang

Affiliations

Xiu Zang: Department of Endocrinology and Central Laboratory, Xuzhou Central Hospital, Xuzhou Institute of Medical Sciences, Xuzhou, China; Xuzhou Clinical School of Xuzhou Medical University, The Affiliated Xuzhou Central Hospital of Nanjing Medical University, The Affiliated Xuzhou Central Hospital of Medical College of Southeast University, Xuzhou, China
Xiangyu Meng: Nanjing Medical University, Jiangsu 211166, China
Xuekui Liu: Department of Endocrinology and Central Laboratory, Xuzhou Central Hospital, Xuzhou Institute of Medical Sciences, Xuzhou, China; Xuzhou Clinical School of Xuzhou Medical University, The Affiliated Xuzhou Central Hospital of Nanjing Medical University, The Affiliated Xuzhou Central Hospital of Medical College of Southeast University, Xuzhou, China
Houfa Geng: Department of Endocrinology and Central Laboratory, Xuzhou Central Hospital, Xuzhou Institute of Medical Sciences, Xuzhou, China; Xuzhou Clinical School of Xuzhou Medical University, The Affiliated Xuzhou Central Hospital of Nanjing Medical University, The Affiliated Xuzhou Central Hospital of Medical College of Southeast University, Xuzhou, China; Corresponding authors.
Jun Liang: Department of Endocrinology and Central Laboratory, Xuzhou Central Hospital, Xuzhou Institute of Medical Sciences, Xuzhou, China; Xuzhou Clinical School of Xuzhou Medical University, The Affiliated Xuzhou Central Hospital of Nanjing Medical University, The Affiliated Xuzhou Central Hospital of Medical College of Southeast University, Xuzhou, China; Postgraduate Workstation of Soochow University, Xuzhou, China; Corresponding authors.

Journal volume & issue: Vol. 36
p. 102441

Abstract

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Objective: To explore the correlation between changes in the body fat ratio (BFR) and peripheral blood inflammatory markers according to smoking status in the adult Chinese male population. Methods: A total of 865 participants (aged 20–70 years) were included. All participants underwent a physical health examination at Xiguzhou Central Hospital between October 2015 and July 2016, including measurements of body mass index (BMI), BFR, white blood cell [WBC] count, and neutrophil–lymphocyte ratio [NLR]. Results: WBCs count and NLR were significantly higher in adult male smokers than in non-smokers (P = 0.00). According to the BFR stratification analysis, WBC count and NLR significantly increased in accordance with BFR (P = 0.00). This finding remained significant after adjusting for relevant confounding factors (P < 0.05). Two-factor stratified analysis of smoking status and BFR showed that WBC count and NLR in the smoking population were higher than in nonsmokers, regardless of BFR. The interaction model showed that BFR and smoking status affected WBC count and NLR changes (P < 0.05). A significant positive correlation was found between WBC count, NLR, and BFR in adult male smokers; however, there was no significant correlation with BMI. There was an interaction between smoking and BFR, both of which synergistically affected changes in inflammatory markers, including WBC count and NLR. Conclusion: WBC count and NLR of smokers with a high BFR were significantly higher than those of nonsmokers with a low BFR. It is important to provide evidence-based medical evidence for social tobacco control and to reduce BFR.

Published in Preventive Medicine Reports

ISSN: 2211-3355 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine
Website: http://www.journals.elsevier.com/preventive-medicine-reports/

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