AIM: To evaluate the clinical effect of anti-VEGF and combined with compound trabeculectomy in the treatment of neovascular glaucoma(NVG).METHODS: A study was performed on the related data of 42 NVG patients(43 eyes)who were admitted to Department of Ophthalmology, the Fourth People's Hospital of Shenyang from January 2017 to June 2019. Blood routine, urine routine, electrocardiogram, visual acuity, intraocular pressure, and Scheimpflug photography were taken after all patients were enrolled, and fundus examination was completed according to the state of the refractive condition. According to the intraocular pressure, lowering intraocular pressure and antibiotic eye drops were taken before surgery. On the third day of admission, the patients were treated with anti-VEGF treatment. The patients divided into the lucentis group and conbercept group according to patient choice. Compound trabeculectomy was performed 72h after injection(subconjunctiva and scleral flap were locally infiltrated with fluorouracil + adjustable suture line+goniosynechialysis). Visual acuity and intraocular pressure were recorded 1d, 1wk, 2wk, 1mo, 2mo, 3mo and 6mo after surgery. Analysis of variance for repeated measurements to compare data before and after surgery, the independent sample t-test was used to compare the differences between groups at each time point. RESULTS: Both lucentis and conbercept could suppress iris neovascularization. There was no significant difference between two groups. The intraocular pressure significantly decreased in most patients 1d, 1wk, 2wk, 1mo, 2mo, 3mo and 6mo after surgery. Vision acuity could be improved in some patients.CONCLUSION: Anti-VEGF and combined with compound trabeculectomy is effective in the treatment of lowering intraocular pressure for NVG. Vision acuity and the quality of life could be improved in some patients.