Targeted calcium influx boosts cytotoxic T lymphocyte function in the tumour microenvironment

Kyun-Do Kim; Seyeon Bae; Tara Capece; Hristina Nedelkovska; Rafael G. de Rubio; Alan V. Smrcka; Chang-Duk Jun; Woojin Jung; Byeonghak Park; Tae-il Kim; Minsoo Kim

doi:10.1038/ncomms15365

Nature Communications (May 2017)

Targeted calcium influx boosts cytotoxic T lymphocyte function in the tumour microenvironment

Kyun-Do Kim,
Seyeon Bae,
Tara Capece,
Hristina Nedelkovska,
Rafael G. de Rubio,
Alan V. Smrcka,
Chang-Duk Jun,
Woojin Jung,
Byeonghak Park,
Tae-il Kim,
Minsoo Kim

Affiliations

Kyun-Do Kim: Department of Microbiology and Immunology, David H. Smith Center for Vaccine Biology and Immunology, University of Rochester
Seyeon Bae: Department of Microbiology and Immunology, David H. Smith Center for Vaccine Biology and Immunology, University of Rochester
Tara Capece: Department of Microbiology and Immunology, David H. Smith Center for Vaccine Biology and Immunology, University of Rochester
Hristina Nedelkovska: Department of Microbiology and Immunology, David H. Smith Center for Vaccine Biology and Immunology, University of Rochester
Rafael G. de Rubio: Department of Pharmacology & Physiology, University of Rochester
Alan V. Smrcka: Department of Pharmacology & Physiology, University of Rochester
Chang-Duk Jun: School of Life Sciences, Immune Synapse and Cell Therapy Research Center, Gwangju Institute of Science and Technology
Woojin Jung: School of Chemical Engineering, Sungkyunkwan University
Byeonghak Park: School of Chemical Engineering, Sungkyunkwan University
Tae-il Kim: School of Chemical Engineering, Sungkyunkwan University
Minsoo Kim: Department of Microbiology and Immunology, David H. Smith Center for Vaccine Biology and Immunology, University of Rochester

DOI: https://doi.org/10.1038/ncomms15365
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 10

Abstract

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Regulatory T cells (Tregs) promote immune suppression in the tumour. Here, the authors show that Tregs suppress cytotoxic T lymphocyte (CTL) activity by impairing Ca2+ signalling and that adoptive transfer of CTLs engineered with an optogenetic control of Ca2+overcome the immune suppression at the tumour site.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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