Nature Communications (Jul 2019)

Genome and epigenome wide studies of neurological protein biomarkers in the Lothian Birth Cohort 1936

  • Robert F. Hillary,
  • Daniel L. McCartney,
  • Sarah E. Harris,
  • Anna J. Stevenson,
  • Anne Seeboth,
  • Qian Zhang,
  • David C. Liewald,
  • Kathryn L. Evans,
  • Craig W. Ritchie,
  • Elliot M. Tucker-Drob,
  • Naomi R. Wray,
  • Allan F. McRae,
  • Peter M. Visscher,
  • Ian J. Deary,
  • Riccardo E. Marioni

DOI
https://doi.org/10.1038/s41467-019-11177-x
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 9

Abstract

Read online

Plasma levels of neurological proteins have the potential to serve as biomarkers for neurological conditions. Here, Hillary et al. perform genome- and epigenome-wide association studies for 92 neurological proteins and identify 41 genomic loci for 33 proteins and 26 CpG sites for 9 proteins.