Zhongguo linchuang yanjiu (Nov 2024)

Correlation and prognostic value of albumin/fibrinogen ratio with myocardial injury in patients with sepsis

  • TIAN Xueyan*, YU Dian, LI Xiaomin, CHEN Xuefeng

DOI
https://doi.org/10.13429/j.cnki.cjcr.2024.11.013
Journal volume & issue
Vol. 37, no. 11
pp. 1709 – 1713

Abstract

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Objective To investigate the level of albumin/fibrinogen ratio (AFR) and its relationship with prognosis in patients with septic myocardial injury. Methods From February 2022 to April 2023, a prospective clinical observational study was conducted to collect 101 patients with sepsis in Lianyungang Hospital Affiliated to Xuzhou Medical University as study subjects. They were divided into myocardial injury group (46 cases) and normal cardiac function group (55 cases) according to whether myocardial injury occurred. The basic clinical data of the two groups were recorded, and peripheral blood was collected within 24 h of admission to test for albumin, fibrinogen, amino-terminal pro-B-type natriuretic peptide (NT-proBNP), high sensitivity troponin I (hsTnI), calcitoninogen (PCT), acute physiology and chronic health evaluation (APACHEⅡ), and sequential organ failure assessment (SOFA). Survival of patients was recorded at 28 days of follow-up. Logistic regression was used to analyze the independent risk factors of septic myocardial injury, ROC curve was used to analyze the clinical diagnostic efficacy of AFR in septic myocardial injury. Results Compared with normal cardiac function group, the levels of albumin and AFR were significantly reduced, while the NT-proBNP, hsTnI, APACHEⅡ scores, and fibrinogen were significantly increased in myocardial injury group (P＜0.05). Elevated AFR was an independent protective factor for myocardial injury in sepsis (OR=0.547, 95%CI: 0.384-0.779, P=0.001). When the AFR cutoff value was 7.07, the AUC for the diagnosis of septic myocardial injury was 0.791 (95%CI: 0.693-0.888), but the combination of hsTnI, NT-proBNP and APACHEⅡ scores had the highest diagnostic value, with an AUC of 0.933 (95%CI: 0.887-0.978).The 28-day survival of sepsis patients with low AFR expression (AFR≤7.07) was significantly lower than that of sepsis patients with high AFR expression (AFR＞7.07, P＜0.05).Conclusion To some extent, AFR can predict the occurrence of myocardial injury and the risk of 28-day death in patients with sepsis.

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