New Aspects of Ambroxol Usage in Pediatric Pulmonology: Looking Through the Lens of Impacting Biofilm

Abstract

The paper analyzes the role of biofilms in the course of respiratory pathology, the mechanisms of formation of microorganism resistance to antibiotics. It is emphasized that abroxol along with a number of pleiotropic effects proved in numerous clinical and experimental studies is able to reduce primary attachment of the microorganisms to the surface in low dosage and to impact biofilm in low dosage by decreasing alginate production providing antibiotic resistance. Ambroxol is proved to influence biofilm development at all stages by several mechanisms, namely direct effect on biofilm, enhancement in antibiotic concentration in pulmonary tissue and lung fluid, anti-oxidant and anti-inflammatory effects, improvement of mucociliary clearance. A complex action of ambroxol expands significantly the range of its usage in pulmonary pathology in children.

Keywords

• pediatric pulmonology
• biofilm, ambroxol