Five-Year Survival Analysis of Renal Transplantation Graft and Affecting Factors

Abstract

Background: Renal transplantation is the appropriate and most effective therapeutic strategy for patients with end-stage renal disease. The aim of this study was to determine the five-year survival rate of renal transplantation graft and affecting factors. Methods: A survival analysis study was performed on the data of 756 renal transplants in Kermanshah, Iran, during 2001 to 2012. Kaplan-Meier, Cox regression methods and log-rank tests were used to estimate the graft survival rate and comparison of cumulative survival difference between the groups was done using STATA software. Findings: Via Kaplan-Meier method, the estimated survival rate of grafts at six months and one, three and five years were 89.0, 87.4, 80.0 and 75.0 percent, respectively. Cox regression model showed that the variables of kinship, donor and recipient sex, and after-surgery creatinine and hemoglobin levels were significantly associated with graft survival rate. Conclusion: The five-year survival rate was 75.0% for renal transplants in the studied center, does not seem satisfactory compared with reported rates of major transplant centers.

Keywords

• Kidney transplantation
• Graft survival
• Cox regression