USP11 controls R-loops by regulating senataxin proteostasis

Mateusz Jurga; Arwa A. Abugable; Alastair S. H. Goldman; Sherif F. El-Khamisy

doi:10.1038/s41467-021-25459-w

Nature Communications (Sep 2021)

USP11 controls R-loops by regulating senataxin proteostasis

Mateusz Jurga,
Arwa A. Abugable,
Alastair S. H. Goldman,
Sherif F. El-Khamisy

Affiliations

Mateusz Jurga: School of Bioscience, Department of Molecular Biology and Biotechnology, The Healthy Lifespan Institute and the Institute of Neuroscience, University of Sheffield
Arwa A. Abugable: School of Bioscience, Department of Molecular Biology and Biotechnology, The Healthy Lifespan Institute and the Institute of Neuroscience, University of Sheffield
Alastair S. H. Goldman: Faculty of Life Sciences, University of Bradford
Sherif F. El-Khamisy: School of Bioscience, Department of Molecular Biology and Biotechnology, The Healthy Lifespan Institute and the Institute of Neuroscience, University of Sheffield

DOI: https://doi.org/10.1038/s41467-021-25459-w
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 18

Abstract

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DNA:RNA hybrids (R-loops) are products of transcription that impact genome integrity and gene expression. Here the authors reveal a mechanism for regulating R-loops in a ubiquitination-dependent manner controlled by the activities of USP11 and KEAP1

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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