Nature Communications (2019-06-01)

Identification of HIV transmitting CD11c+ human epidermal dendritic cells

  • Kirstie M. Bertram,
  • Rachel A. Botting,
  • Heeva Baharlou,
  • Jake W. Rhodes,
  • Hafsa Rana,
  • J. Dinny Graham,
  • Ellis Patrick,
  • James Fletcher,
  • Toby M. Plasto,
  • Naomi R. Truong,
  • Caroline Royle,
  • Chloe M. Doyle,
  • Orion Tong,
  • Najla Nasr,
  • Laith Barnouti,
  • Mark P. Kohout,
  • Andrew J. Brooks,
  • Michael P. Wines,
  • Peter Haertsch,
  • Jake Lim,
  • Martijn P. Gosselink,
  • Grahame Ctercteko,
  • Jacob D. Estes,
  • Melissa J. Churchill,
  • Paul U. Cameron,
  • Eric Hunter,
  • Muzlifah A. Haniffa,
  • Anthony L. Cunningham,
  • Andrew N. Harman

DOI
https://doi.org/10.1038/s41467-019-10697-w
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 15

Abstract

Read online

Composition and function of immune populations at barrier surfaces is crucial for response to infection. Here, the authors identify a population of dendritic cells in human epidermis, abundant in anogenital epithelia and distinct from Langerhans cells by surface phenotype and by high capacity for HIV infection and transmission.