Nature Communications (Jun 2019)
Identification of HIV transmitting CD11c+ human epidermal dendritic cells
- Kirstie M. Bertram,
- Rachel A. Botting,
- Heeva Baharlou,
- Jake W. Rhodes,
- Hafsa Rana,
- J. Dinny Graham,
- Ellis Patrick,
- James Fletcher,
- Toby M. Plasto,
- Naomi R. Truong,
- Caroline Royle,
- Chloe M. Doyle,
- Orion Tong,
- Najla Nasr,
- Laith Barnouti,
- Mark P. Kohout,
- Andrew J. Brooks,
- Michael P. Wines,
- Peter Haertsch,
- Jake Lim,
- Martijn P. Gosselink,
- Grahame Ctercteko,
- Jacob D. Estes,
- Melissa J. Churchill,
- Paul U. Cameron,
- Eric Hunter,
- Muzlifah A. Haniffa,
- Anthony L. Cunningham,
- Andrew N. Harman
Affiliations
- Kirstie M. Bertram
- Centre for Virus Research, The Westmead Institute for Medical Research
- Rachel A. Botting
- Centre for Virus Research, The Westmead Institute for Medical Research
- Heeva Baharlou
- Centre for Virus Research, The Westmead Institute for Medical Research
- Jake W. Rhodes
- Centre for Virus Research, The Westmead Institute for Medical Research
- Hafsa Rana
- Centre for Virus Research, The Westmead Institute for Medical Research
- J. Dinny Graham
- Centre for Virus Research, The Westmead Institute for Medical Research
- Ellis Patrick
- Centre for Virus Research, The Westmead Institute for Medical Research
- James Fletcher
- Institute of Cellular Medicine, Newcastle University
- Toby M. Plasto
- Centre for Virus Research, The Westmead Institute for Medical Research
- Naomi R. Truong
- Centre for Virus Research, The Westmead Institute for Medical Research
- Caroline Royle
- Centre for Virus Research, The Westmead Institute for Medical Research
- Chloe M. Doyle
- Centre for Virus Research, The Westmead Institute for Medical Research
- Orion Tong
- Centre for Virus Research, The Westmead Institute for Medical Research
- Najla Nasr
- Centre for Virus Research, The Westmead Institute for Medical Research
- Laith Barnouti
- Australia Plastic Surgery
- Mark P. Kohout
- Australia Plastic Surgery
- Andrew J. Brooks
- Westmead Hospital
- Michael P. Wines
- Royal North Shore Hospital
- Peter Haertsch
- Burns Unit, Concord Repatriation General Hospital
- Jake Lim
- Dr Jake Lim PLC
- Martijn P. Gosselink
- Centre for Virus Research, The Westmead Institute for Medical Research
- Grahame Ctercteko
- Centre for Virus Research, The Westmead Institute for Medical Research
- Jacob D. Estes
- AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc
- Melissa J. Churchill
- School of Health and Biomedical Sciences, College of Science, Engineering and Health, RMIT University
- Paul U. Cameron
- The Peter Doherty Institute for Infection and Immunity
- Eric Hunter
- Emory Vaccine Center
- Muzlifah A. Haniffa
- Institute of Cellular Medicine, Newcastle University
- Anthony L. Cunningham
- Centre for Virus Research, The Westmead Institute for Medical Research
- Andrew N. Harman
- Centre for Virus Research, The Westmead Institute for Medical Research
- DOI
- https://doi.org/10.1038/s41467-019-10697-w
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 15
Abstract
Composition and function of immune populations at barrier surfaces is crucial for response to infection. Here, the authors identify a population of dendritic cells in human epidermis, abundant in anogenital epithelia and distinct from Langerhans cells by surface phenotype and by high capacity for HIV infection and transmission.
