NDRG2: a novel Alzheimer's disease associated protein

Cathy Mitchelmore; Stine Büchmann-Møller; Lene Rask; Mark J West; Juan C Troncoso; Niels A Jensen

Neurobiology of Disease (Jun 2004)

NDRG2: a novel Alzheimer's disease associated protein

Cathy Mitchelmore,
Stine Büchmann-Møller,
Lene Rask,
Mark J West,
Juan C Troncoso,
Niels A Jensen

Affiliations

Cathy Mitchelmore: Laboratory of Mammalian Molecular Genetics, The Panum Institute 6.5, University of Copenhagen, 2200 Copenhagen N, Denmark; Neurostereology Laboratory, Department of Neurobiology, University of Aarhus, Aarhus, Denmark; Neuropathology Laboratory, Johns Hopkins University Medical School, Baltimore, MD 21205-2196, USA
Stine Büchmann-Møller: Laboratory of Mammalian Molecular Genetics, The Panum Institute 6.5, University of Copenhagen, 2200 Copenhagen N, Denmark; Neurostereology Laboratory, Department of Neurobiology, University of Aarhus, Aarhus, Denmark; Neuropathology Laboratory, Johns Hopkins University Medical School, Baltimore, MD 21205-2196, USA
Lene Rask: Laboratory of Mammalian Molecular Genetics, The Panum Institute 6.5, University of Copenhagen, 2200 Copenhagen N, Denmark; Neurostereology Laboratory, Department of Neurobiology, University of Aarhus, Aarhus, Denmark; Neuropathology Laboratory, Johns Hopkins University Medical School, Baltimore, MD 21205-2196, USA
Mark J West: Laboratory of Mammalian Molecular Genetics, The Panum Institute 6.5, University of Copenhagen, 2200 Copenhagen N, Denmark; Neurostereology Laboratory, Department of Neurobiology, University of Aarhus, Aarhus, Denmark; Neuropathology Laboratory, Johns Hopkins University Medical School, Baltimore, MD 21205-2196, USA
Juan C Troncoso: Laboratory of Mammalian Molecular Genetics, The Panum Institute 6.5, University of Copenhagen, 2200 Copenhagen N, Denmark; Neurostereology Laboratory, Department of Neurobiology, University of Aarhus, Aarhus, Denmark; Neuropathology Laboratory, Johns Hopkins University Medical School, Baltimore, MD 21205-2196, USA
Niels A Jensen: Laboratory of Mammalian Molecular Genetics, The Panum Institute 6.5, University of Copenhagen, 2200 Copenhagen N, Denmark; Neurostereology Laboratory, Department of Neurobiology, University of Aarhus, Aarhus, Denmark; Neuropathology Laboratory, Johns Hopkins University Medical School, Baltimore, MD 21205-2196, USA

Journal volume & issue: Vol. 16, no. 1
pp. 48 – 58

Abstract

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Our understanding of the genes involved in Alzheimer's disease (AD) is incomplete. Using subtractive cloning technology, we discovered that the α/β-hydrolase fold protein gene NDRG2 (NDRG family member 2) is upregulated at both the RNA and protein levels in AD brains. Expression of NDRG2 in affected brains was revealed in (1) cortical pyramidal neurons, (2) senile plaques and (3) cellular processes of dystrophic neurons. Overexpression of two splice variants encoding a long and short NDRG2 isoform in hippocampal pyramidal neurons of transgenic mice resulted in localization of both isoforms to dendritic processes. Taken together, our findings suggest that NDRG2 upregulation is associated with disease pathogenesis in the human brain and provide new insight into the molecular changes that occur in AD.

Published in Neurobiology of Disease

ISSN: 0969-9961 (Print); 1095-953X (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: https://www.journals.elsevier.com/neurobiology-of-disease

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