497 PTT-4256 is a first-in-class small molecule inhibitor of GPR65 that counteracts the low pH-dependent immunosuppressive effects on immune cells and displays pronounced anti-tumor activity in mice

• David Miller,
• Alastair Corbin,
• Barbara Young,
• Preeti Singh,
• Tobias Bopp,
• Darryl Turner,
• Barbara Cipriani,
• Alan Naylor,
• Gavin Milne,
• Rupert Satchell,
• Mussa Quareshy,
• Sourav Sarkar,
• Tobias Moechel,
• Philip MacFaul,
• Stuart Paine,
• Oliver Horne,
• Jessica Holien,
• Anastasia Nika,
• Gavin Knox,
• Toszka Bohn,
• Tom McCarthy,
• Stuart Hughes

Affiliations

David Miller

Open Health Care, London, UK

Alastair Corbin

2Kennedy Institute of Rheumatology, University of Oxford

Barbara Young

19Department of Medicine, McGill University Health Centre, Montreal, Quebec, Canada

Preeti Singh

1 Division of Genetics and Metabolism, Department of Pediatrics, University of California, Irvine, California, USA

Tobias Bopp

4 Institute for Immunology, University Medical Center, Johannes Gutenberg University, Mainz, Germany

Darryl Turner

Concept Life Sciences, Edinburgh, UK

Barbara Cipriani

1Pathios Therapeutics Ltd., Abingdon, Oxfordshire, UK

Alan Naylor

1Pathios Therapeutics Ltd., Abingdon, Oxfordshire, UK

Gavin Milne

3Sygnature Discovery Ltd., Nottingham, Nottinghamshire, UK

Rupert Satchell

3Sygnature Discovery Ltd., Nottingham, Nottinghamshire, UK

Mussa Quareshy

3Sygnature Discovery Ltd., Nottingham, Nottinghamshire, UK

Sourav Sarkar

3Sygnature Discovery Ltd., Nottingham, Nottinghamshire, UK

Tobias Moechel

3Sygnature Discovery Ltd., Nottingham, Nottinghamshire, UK

Philip MacFaul

3Sygnature Discovery Ltd., Nottingham, Nottinghamshire, UK

Stuart Paine

3Sygnature Discovery Ltd., Nottingham, Nottinghamshire, UK

Oliver Horne

3Sygnature Discovery Ltd., Nottingham, Nottinghamshire, UK

Jessica Holien

4RMIT University, Melbourne, VIC, Australia

Anastasia Nika

5Concept Life Sciences Ltd., Edinburgh, UK

Gavin Knox

5Concept Life Sciences Ltd., Edinburgh, UK

Toszka Bohn

7University Medical Centre, Mainz, Rhineland-Palatinate, Germany

Tom McCarthy

2Pathios Therapeutics Ltd, Oxford, Oxfordshire, UK

Stuart Hughes

1Pathios Therapeutics Ltd., Abingdon, Oxfordshire, UK