Journal for ImmunoTherapy of Cancer (Nov 2023)
497 PTT-4256 is a first-in-class small molecule inhibitor of GPR65 that counteracts the low pH-dependent immunosuppressive effects on immune cells and displays pronounced anti-tumor activity in mice
- David Miller,
- Alastair Corbin,
- Barbara Young,
- Preeti Singh,
- Tobias Bopp,
- Darryl Turner,
- Barbara Cipriani,
- Alan Naylor,
- Gavin Milne,
- Rupert Satchell,
- Mussa Quareshy,
- Sourav Sarkar,
- Tobias Moechel,
- Philip MacFaul,
- Stuart Paine,
- Oliver Horne,
- Jessica Holien,
- Anastasia Nika,
- Gavin Knox,
- Toszka Bohn,
- Tom McCarthy,
- Stuart Hughes
Affiliations
- David Miller
- Open Health Care, London, UK
- Alastair Corbin
- 2Kennedy Institute of Rheumatology, University of Oxford
- Barbara Young
- 19Department of Medicine, McGill University Health Centre, Montreal, Quebec, Canada
- Preeti Singh
- 1 Division of Genetics and Metabolism, Department of Pediatrics, University of California, Irvine, California, USA
- Tobias Bopp
- 4 Institute for Immunology, University Medical Center, Johannes Gutenberg University, Mainz, Germany
- Darryl Turner
- Concept Life Sciences, Edinburgh, UK
- Barbara Cipriani
- 1Pathios Therapeutics Ltd., Abingdon, Oxfordshire, UK
- Alan Naylor
- 1Pathios Therapeutics Ltd., Abingdon, Oxfordshire, UK
- Gavin Milne
- 3Sygnature Discovery Ltd., Nottingham, Nottinghamshire, UK
- Rupert Satchell
- 3Sygnature Discovery Ltd., Nottingham, Nottinghamshire, UK
- Mussa Quareshy
- 3Sygnature Discovery Ltd., Nottingham, Nottinghamshire, UK
- Sourav Sarkar
- 3Sygnature Discovery Ltd., Nottingham, Nottinghamshire, UK
- Tobias Moechel
- 3Sygnature Discovery Ltd., Nottingham, Nottinghamshire, UK
- Philip MacFaul
- 3Sygnature Discovery Ltd., Nottingham, Nottinghamshire, UK
- Stuart Paine
- 3Sygnature Discovery Ltd., Nottingham, Nottinghamshire, UK
- Oliver Horne
- 3Sygnature Discovery Ltd., Nottingham, Nottinghamshire, UK
- Jessica Holien
- 4RMIT University, Melbourne, VIC, Australia
- Anastasia Nika
- 5Concept Life Sciences Ltd., Edinburgh, UK
- Gavin Knox
- 5Concept Life Sciences Ltd., Edinburgh, UK
- Toszka Bohn
- 7University Medical Centre, Mainz, Rhineland-Palatinate, Germany
- Tom McCarthy
- 2Pathios Therapeutics Ltd, Oxford, Oxfordshire, UK
- Stuart Hughes
- 1Pathios Therapeutics Ltd., Abingdon, Oxfordshire, UK
- DOI
- https://doi.org/10.1136/jitc-2023-SITC2023.0497
- Journal volume & issue
-
Vol. 11,
no. Suppl 1
Abstract
No abstracts available.