Nature Communications (Oct 2020)

Structural insights into assembly of the ribosomal nascent polypeptide exit tunnel

  • Daniel M. Wilson,
  • Yu Li,
  • Amber LaPeruta,
  • Michael Gamalinda,
  • Ning Gao,
  • John L. Woolford

DOI
https://doi.org/10.1038/s41467-020-18878-8
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 15

Abstract

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The nascent polypeptide exit tunnel (NPET) is a functional center of the large ribosomal subunit through which the nascent polypeptide chains travel from the peptidyltransferase center (PTC). Here the authors provide structural insight into NPET maturation and how it is linked to other aspects of ribosome biogenesis.