International Journal of General Medicine (Dec 2022)
Detecting Preeclampsia Severity Using Maternal-Obstetrical Characteristics and Complete Blood Cell Counts
Abstract
Hsiao-Wen Lu,1,2 Han-Shui Hsu2 1Department of Obstetrics and Gynecology, Cardinal Tien Hospital, New Taipei City, Taiwan; 2Institute of Emergency and Critical Care Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei, TaiwanCorrespondence: Han-Shui Hsu, Institute of Emergency and Critical Care Medicine, School of Medicine, National Yang Ming Chiao Tung University, No. 155, Sec. 2, Linong St, Beitou Dist, Taipei, 112, Taiwan, Tel +886-2-22875-7546, Email [email protected]: This study aimed to use the combination of maternal-obstetrical characteristics (MOCs) and complete blood cell counts (CBCs) with different red blood cell (RBC) indices as an alternative tool to detect preeclampsia (PE) severity immediately before delivery.Patients and Methods: This retrospective study included all singleton pregnancies delivered after 24 weeks of gestation from April 2016 to April 2020. Patients were divided into four different groups: non-hypertensive (NH), gestational hypertension (GH), PE, and severe PE (SPE). Univariate and forward stepwise multivariate logistic regression analysis was conducted using MOCs, CBCs, and RBC indices. The calculation was performed between SPE and other non-hypertensive and hypertensive (GH, PE) groups. Moreover, the area under the curve (AUC) for the receiver operating characteristic curve, sensitivity, and specificity were estimated.Results: The combined variables for differentiating SPE from NH were maternal age > 29.5 years, weight > 27.24, gestational age 29.5 years, body mass index > 25.28, gestational age 32.5 years, mean corpuscular hemoglobin concentration > 34.55 g/dL, and Siradah indices < 40.05 (AUC, 0.745; 95% CI, 0.656– 0.833).Conclusion: The combination of selected variables from MOCs and CBCs with RBC indices before delivery showed satisfactory results for detecting PE severity.Keywords: hypertension, pregnancy, preeclampsia, preeclampsia severity, complete blood counts
