Divergent effects of central melanocortin signalling on fat and sucrose preference in humans

Agatha A. van der Klaauw; Julia M. Keogh; Elana Henning; Cheryl Stephenson; Sarah Kelway; Victoria M. Trowse; Naresh Subramanian; Stephen O’Rahilly; Paul C. Fletcher; I. Sadaf Farooqi

doi:10.1038/ncomms13055

Nature Communications (Oct 2016)

Divergent effects of central melanocortin signalling on fat and sucrose preference in humans

Agatha A. van der Klaauw,
Julia M. Keogh,
Elana Henning,
Cheryl Stephenson,
Sarah Kelway,
Victoria M. Trowse,
Naresh Subramanian,
Stephen O’Rahilly,
Paul C. Fletcher,
I. Sadaf Farooqi

Affiliations

Agatha A. van der Klaauw: Clinical Biochemistry, University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome Trust-MRC Institute of Metabolic Science
Julia M. Keogh: Clinical Biochemistry, University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome Trust-MRC Institute of Metabolic Science
Elana Henning: Clinical Biochemistry, University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome Trust-MRC Institute of Metabolic Science
Cheryl Stephenson: Clinical Biochemistry, University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome Trust-MRC Institute of Metabolic Science
Sarah Kelway: Clinical Biochemistry, University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome Trust-MRC Institute of Metabolic Science
Victoria M. Trowse: Clinical Biochemistry, University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome Trust-MRC Institute of Metabolic Science
Naresh Subramanian: Clinical Biochemistry, University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome Trust-MRC Institute of Metabolic Science
Stephen O’Rahilly: Clinical Biochemistry, University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome Trust-MRC Institute of Metabolic Science
Paul C. Fletcher: Clinical Biochemistry, University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome Trust-MRC Institute of Metabolic Science
I. Sadaf Farooqi: Clinical Biochemistry, University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome Trust-MRC Institute of Metabolic Science

DOI: https://doi.org/10.1038/ncomms13055
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 5

Abstract

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Hypothalamic melanocortin-4-receptors (MC4R) regulate food preference in rodents, but their role in humans is unclear. Here, the authors perform food preference and liking tests in humans with MC4R mutations and find that they prefer fatty food more, but sweet food less, than people without MC4R mutations.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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