Role of immune inflammation in the pathogenesis of osteoarthrosis and possibilities of correction of immune impairments

Abstract

A great role in the pathogenesis of osteoarthrosis has been recently assigned to immune impairments, particularly to the involvement of proinflammatory cytokines (interleukin 1 (IL-1), tumor necrosis factor-α (TNF-α)) that activate catabolic processes not only in cartilage tissue, but also in the subchodral bone and other articular structures. Non-steroidal anti-inflammatory drugs, symptomatic slow-acting agents (chondroitin and glucosamine sulfate), as well as diacerein that blocks IL-1 directly and TNF-α indirectly, reduce the activity of cytokines to some extent.

Keywords

• osteoarthrosis
• nflammation,
• non-steroidal anti-inflammatory drugs
• diacerein