Clinical and cost-effectiveness analysis of the methods of therapy and prevention of andrological pathologies using drugs based on ozone and nano-biomaterials
Abstract
Practical implementation of the latest pharmacological developments is possible provided that their clinical and economic efficiency is assessed. At the same time, the issues of economic feasibility of using the latest diagnostic techniques, as well as means of therapy and prevention of the male reproductive pathologies system remain poorly studied. The aim of the work was to analyze the cost-effectiveness of methods of therapy and prevention of andrological diseases with drugs based on ozonated and nanobiomaterials. The following research tasks were set: to establish the clinical and economic effectiveness of the method of therapy of males for nonspecific balanoposthitis with ozone-containing drugs OCO and Prozon and to determine the economic effect of treatment and prevention methods of alimentary and toxic reproductive diseases in males using drugs based on nanobiomatersals. Clinical and economic efficacy of the treatment method of males with nonspecific balanoposthitis was established by estimating the cost of treatment of animals group with OCO and Prozon by changes in the diseaseduration from treatment to recovery of the fetus compared with conventional antibiotic therapy. The economic effect of therapy and prevention methodsof alimentary and toxic reproductive diseases was evaluated by changes in sperm quality and calculated the average number of additional sperm doses received from the males. The duration of the period from the beginning of treatment to recovery in boars with the use of ozone-containing drugs was: when using OKO – 6.7 ± 0.18 days, and Prozon – 6.1 ± 0.21 days, which was less by 0.9–1.5 days compared with the introduction of gentamicin ointment. And in bulls when using the drug OKO – by 6.7 ± 0.33 days, and Prozon – 5.14 ± 0.26 days, which was less by 1.1–2.7 days. At the same time, the cost of treatment of one male has decreased by 42.3 % with the use of OKO and 37.5 % – Prozon. Despite the higher cost of the drug Prozon, its use is more effective due to faster recovery of the malts. An increase in ejaculate volume, sperm motility, concentration based on the results of correction of alimentary and toxic reproductive diseases has been established; the number of sperm with morphological abnormalities, on the other side, was probably reduced. The complex drug “Karafand+OV,Zn” had a high economic effect due to the possibility of additional receipt 6 spermodoses from the boar and 22 from the bull for the correction of reproductive diseases of the alimentary type and 6 spermodoses from the boar and 20 from the bull – toxic type.
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