Protein structure and folding pathway prediction based on remote homologs recognition using PAthreader

Kailong Zhao; Yuhao Xia; Fujin Zhang; Xiaogen Zhou; Stan Z. Li; Guijun Zhang

doi:10.1038/s42003-023-04605-8

Communications Biology (Mar 2023)

Protein structure and folding pathway prediction based on remote homologs recognition using PAthreader

Kailong Zhao,
Yuhao Xia,
Fujin Zhang,
Xiaogen Zhou,
Stan Z. Li,
Guijun Zhang

Affiliations

Kailong Zhao: College of Information Engineering, Zhejiang University of Technology
Yuhao Xia: College of Information Engineering, Zhejiang University of Technology
Fujin Zhang: College of Information Engineering, Zhejiang University of Technology
Xiaogen Zhou: College of Information Engineering, Zhejiang University of Technology
Stan Z. Li: AI Lab, Research Center for Industries of the Future, Westlake University
Guijun Zhang: College of Information Engineering, Zhejiang University of Technology

DOI: https://doi.org/10.1038/s42003-023-04605-8
Journal volume & issue: Vol. 6, no. 1
pp. 1 – 14

Abstract

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PAthreader generates templates of remote homologous structures to improve protein structure prediction by AlphaFold2 and predict folding pathways under the hypothesis that folding information is evolutionarily conserved in remote homologs.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal