eLife (Dec 2019)
MouseBytes, an open-access high-throughput pipeline and database for rodent touchscreen-based cognitive assessment
- Flavio H Beraldo,
- Daniel Palmer,
- Sara Memar,
- David I Wasserman,
- Wai-Jane V Lee,
- Shuai Liang,
- Samantha D Creighton,
- Benjamin Kolisnyk,
- Matthew F Cowan,
- Justin Mels,
- Talal S Masood,
- Chris Fodor,
- Mohammed A Al-Onaizi,
- Robert Bartha,
- Tom Gee,
- Lisa M Saksida,
- Timothy J Bussey,
- Stephen S Strother,
- Vania F Prado,
- Boyer D Winters,
- Marco AM Prado
Affiliations
- Flavio H Beraldo
- ORCiD
- Robarts Research Institute, The University of Western Ontario, Ontario, Canada; Graduate Program in Neuroscience, The University of Western Ontario, Ontario, Canada; Department of Physiology and Pharmacology, The University of Western Ontario, Ontario, Canada
- Daniel Palmer
- ORCiD
- Robarts Research Institute, The University of Western Ontario, Ontario, Canada; Department of Psychology and Neuroscience Program, University of Guelph, Guelph, Canada
- Sara Memar
- Robarts Research Institute, The University of Western Ontario, Ontario, Canada
- David I Wasserman
- Robarts Research Institute, The University of Western Ontario, Ontario, Canada; Department of Psychology and Neuroscience Program, University of Guelph, Guelph, Canada
- Wai-Jane V Lee
- Robarts Research Institute, The University of Western Ontario, Ontario, Canada; Graduate Program in Neuroscience, The University of Western Ontario, Ontario, Canada
- Shuai Liang
- Rotman Research Institute, Baycrest Hospital, Toronto, Canada
- Samantha D Creighton
- Department of Psychology and Neuroscience Program, University of Guelph, Guelph, Canada
- Benjamin Kolisnyk
- Robarts Research Institute, The University of Western Ontario, Ontario, Canada; Graduate Program in Neuroscience, The University of Western Ontario, Ontario, Canada
- Matthew F Cowan
- Robarts Research Institute, The University of Western Ontario, Ontario, Canada
- Justin Mels
- Robarts Research Institute, The University of Western Ontario, Ontario, Canada; Graduate Program in Neuroscience, The University of Western Ontario, Ontario, Canada
- Talal S Masood
- Robarts Research Institute, The University of Western Ontario, Ontario, Canada; Graduate Program in Neuroscience, The University of Western Ontario, Ontario, Canada
- Chris Fodor
- Robarts Research Institute, The University of Western Ontario, Ontario, Canada
- Mohammed A Al-Onaizi
- Robarts Research Institute, The University of Western Ontario, Ontario, Canada; Department of Anatomy and Cell Biology, The University of Western Ontario, Ontario, Canada
- Robert Bartha
- Robarts Research Institute, The University of Western Ontario, Ontario, Canada; Department of Medical Biophysics, The University of Western Ontario, London, Canada
- Tom Gee
- Rotman Research Institute, Baycrest Hospital, Toronto, Canada
- Lisa M Saksida
- Robarts Research Institute, The University of Western Ontario, Ontario, Canada; Department of Physiology and Pharmacology, The University of Western Ontario, Ontario, Canada; Brain and Mind Institute, The University of Western Ontario, Ontario, Canada
- Timothy J Bussey
- Robarts Research Institute, The University of Western Ontario, Ontario, Canada; Department of Physiology and Pharmacology, The University of Western Ontario, Ontario, Canada; Brain and Mind Institute, The University of Western Ontario, Ontario, Canada
- Stephen S Strother
- ORCiD
- Rotman Research Institute, Baycrest Hospital, Toronto, Canada; Department of Medical Biophysics, University of Toronto, Toronto, Canada
- Vania F Prado
- Robarts Research Institute, The University of Western Ontario, Ontario, Canada; Graduate Program in Neuroscience, The University of Western Ontario, Ontario, Canada; Department of Physiology and Pharmacology, The University of Western Ontario, Ontario, Canada; Department of Anatomy and Cell Biology, The University of Western Ontario, Ontario, Canada
- Boyer D Winters
- ORCiD
- Department of Psychology and Neuroscience Program, University of Guelph, Guelph, Canada
- Marco AM Prado
- ORCiD
- Robarts Research Institute, The University of Western Ontario, Ontario, Canada; Graduate Program in Neuroscience, The University of Western Ontario, Ontario, Canada; Department of Physiology and Pharmacology, The University of Western Ontario, Ontario, Canada; Department of Anatomy and Cell Biology, The University of Western Ontario, Ontario, Canada
- DOI
- https://doi.org/10.7554/eLife.49630
- Journal volume & issue
-
Vol. 8
Abstract
Open Science has changed research by making data accessible and shareable, contributing to replicability to accelerate and disseminate knowledge. However, for rodent cognitive studies the availability of tools to share and disseminate data is scarce. Automated touchscreen-based tests enable systematic cognitive assessment with easily standardised outputs that can facilitate data dissemination. Here we present an integration of touchscreen cognitive testing with an open-access database public repository (mousebytes.ca), as well as a Web platform for knowledge dissemination (https://touchscreencognition.org). We complement these resources with the largest dataset of age-dependent high-level cognitive assessment of mouse models of Alzheimer’s disease, expanding knowledge of affected cognitive domains from male and female mice of three strains. We envision that these new platforms will enhance sharing of protocols, data availability and transparency, allowing meta-analysis and reuse of mouse cognitive data to increase the replicability/reproducibility of datasets.
Keywords
- Alzheimer's disease
- amyloid-beta plaques
- open-access database
- touchscreen
- high-throughput screening
- cognition
