Linking asymmetric cell division, CD8+ T cell fate, and signal strength
Jyoti Pokharel,
Carmen Gerlach
Affiliations
Jyoti Pokharel
Division of Rheumatology, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, 17176 Stockholm, Sweden; Center for Molecular Medicine, Karolinska University Hospital, 17176 Stockholm, Sweden
Carmen Gerlach
Division of Rheumatology, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, 17176 Stockholm, Sweden; Center for Molecular Medicine, Karolinska University Hospital, 17176 Stockholm, Sweden; Corresponding author
Through live imaging of CD8+ T cells carrying a fate reporter, Gräbnitz et al. directly linked (a)symmetric division to T cell fate.1 Asymmetry during the first division ensured the generation of stem-like CD8+ T cells following strong T cell stimulation.
