Research Center for Respiratory Diseases (CEPR), Team: “Proteolytic Mechanisms in Inflammation”, University of Tours, INSERM, UMR 1100, F-37032 Tours, France
Stéphanie Letast
Research Center for Respiratory Diseases (CEPR), Team: “Proteolytic Mechanisms in Inflammation”, University of Tours, INSERM, UMR 1100, F-37032 Tours, France
Thomas Robert
Integrative Biology of Marine Models Laboratory (LBI2M), Sorbonne University, CNRS, UMR8227, F-29680 Roscoff, France
Stéphane Bach
Integrative Biology of Marine Models Laboratory (LBI2M), Sorbonne University, CNRS, UMR8227, F-29680 Roscoff, France
Noël Pinaud
Institut des Sciences Moléculaires (ISM), University of Bordeaux, CNRS, UMR 5255, F-33405 Talence, France
Nicolas Joubert
Research Center for Respiratory Diseases (CEPR), Team: “Proteolytic Mechanisms in Inflammation”, University of Tours, INSERM, UMR 1100, F-37032 Tours, France
Marie-Claude Viaud-Massuard
Research Center for Respiratory Diseases (CEPR), Team: “Proteolytic Mechanisms in Inflammation”, University of Tours, INSERM, UMR 1100, F-37032 Tours, France
Jean Guillon
ARNA Laboratory, University of Bordeaux, INSERM U12132-UMR CNRS 5320, F-33076 Bordeaux, France
Cédric Logé
Department of Medicinal Chemistry, IICIMED-UR1155, IRS2, Nantes University, F-44200 Nantes, France
Caroline Denevault-Sabourin
Research Center for Respiratory Diseases (CEPR), Team: “Proteolytic Mechanisms in Inflammation”, University of Tours, INSERM, UMR 1100, F-37032 Tours, France
Potassium 6-oxo-7,13,16,22-tetraazatetracyclo[12.6.2.18,12.017,21]tricosa-1(20),8(23),9,11,14,16,18,21-octaen-2-yne-15-carboxylate was synthesized through a multi-step pathway, starting from commercially available 3-iodo-1,2-phenylenediamine. Structure characterization of this new substituted macrocyclic quinoxaline compound was achieved using 1H NMR, 13C NMR, and HRMS spectral analysis. This new macrocyclic derivative demonstrated submicromolar potency on both Pim-1 and Pim-2 isoforms, with an interesting selectivity profile against a selected panel of human kinases.
