Evaluation of cell penetrating peptide coated Mn:ZnS nanoparticles for paclitaxel delivery to cancer cells

N. Sanoj Rejinold; Yunho Han; Jisang Yoo; Hae Yong Seok; Ji Ho Park; Yeu-Chun Kim

doi:10.1038/s41598-018-20255-x

Scientific Reports (Jan 2018)

Evaluation of cell penetrating peptide coated Mn:ZnS nanoparticles for paclitaxel delivery to cancer cells

N. Sanoj Rejinold,
Yunho Han,
Jisang Yoo,
Hae Yong Seok,
Ji Ho Park,
Yeu-Chun Kim

Affiliations

N. Sanoj Rejinold: Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology (KAIST)
Yunho Han: Department of Brain and Bioengineering, Institute of Health Science and Technology, Korea Advanced Institute of Science and Technology (KAIST)
Jisang Yoo: Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology (KAIST)
Hae Yong Seok: Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology (KAIST)
Ji Ho Park: Department of Brain and Bioengineering, Institute of Health Science and Technology, Korea Advanced Institute of Science and Technology (KAIST)
Yeu-Chun Kim: Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology (KAIST)

DOI: https://doi.org/10.1038/s41598-018-20255-x
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 11

Abstract

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Abstract This work aimed at formulating paclitaxel (PTX) loaded cell penetrating peptide (CPP) coated Mn doped ZnS nanoparticles (Mn:ZnS NPs) for improved anti-cancer efficacy in vitro and in vivo. The developed PTX loaded Mn:ZnS NPs with different CPPs (PEN, pVEC and R9) showed enhanced anti-cancer effect compared to bare PTX, which has been validated by MTT assay followed by apoptosis assay and DNA fragmentation analysis. The in vivo bio-distribution and anti-cancer efficacy was studied on breast cancer xenograft model showing maximum tumor localization and enhanced therapeutic efficacy with R9 coated Mn:ZnS NPs (R9:Mn:ZnS NPs) and was confirmed by H/E staining. Thus, R9:Mn:ZnS NPs could be an ideal theranostic nano-carrier for PTX with enhanced the rapeutic efficacy toward cancer cells, where penetration and sustainability of therapeutics are essential.

Published in Scientific Reports

ISSN: 2045-2322 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Medicine; Science
Website: https://www.nature.com/srep/

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