An Osmotic Laxative Renders Mice Susceptible to Prolonged Clostridioides difficile Colonization and Hinders Clearance

mSphere (Oct 2021)

Affiliations

Sarah Tomkovich: ORCiD; Department of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, USA
Ana Taylor: Department of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, USA
Jacob King: Department of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, USA
Joanna Colovas: Department of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, USA
Lucas Bishop: Department of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, USA
Kathryn McBride: Department of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, USA
Sonya Royzenblat: Department of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, USA
Nicholas A. Lesniak: Department of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, USA
Ingrid L. Bergin: Unit for Laboratory Animal Medicine, University of Michigan, Ann Arbor, Michigan, USA
Patrick D. Schloss: ORCiD; Department of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, USA

Abstract

Diarrheal samples from patients taking laxatives are typically rejected for Clostridioides difficileC. difficile