Nature Communications (Mar 2021)

Immune suppressive activity of myeloid-derived suppressor cells in cancer requires inactivation of the type I interferon pathway

  • Kevin Alicea-Torres,
  • Emilio Sanseviero,
  • Jun Gui,
  • Jinyun Chen,
  • Filippo Veglia,
  • Qiujin Yu,
  • Laxminarasimha Donthireddy,
  • Andrew Kossenkov,
  • Cindy Lin,
  • Shuyu Fu,
  • Charles Mulligan,
  • Brian Nam,
  • Gregory Masters,
  • Fred Denstman,
  • Joseph Bennett,
  • Neil Hockstein,
  • Agnieszka Rynda-Apple,
  • Yulia Nefedova,
  • Serge Y. Fuchs,
  • Dmitry I. Gabrilovich

DOI
https://doi.org/10.1038/s41467-021-22033-2
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 13

Abstract

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The role of type I interferon signalling in the control of myeloid derived suppressor cells (MDSC) activity remains controversial. Here the authors show that downregulation of type I interferon receptor is observed in MDSC from cancer patients and tumor-bearing mice and is required for the activation of their immune suppressive properties.