Design principles for rapid folding of knotted DNA nanostructures

Vid Kočar; John S. Schreck; Slavko Čeru; Helena Gradišar; Nino Bašić; Tomaž Pisanski; Jonathan P. K. Doye; Roman Jerala

doi:10.1038/ncomms10803

Nature Communications (Feb 2016)

Design principles for rapid folding of knotted DNA nanostructures

Vid Kočar,
John S. Schreck,
Slavko Čeru,
Helena Gradišar,
Nino Bašić,
Tomaž Pisanski,
Jonathan P. K. Doye,
Roman Jerala

Affiliations

Vid Kočar: Department of Biotechnology, National Institute of Chemistry
John S. Schreck: Department of Chemistry, Physical and Theoretical Chemistry Laboratory, University of Oxford
Slavko Čeru: Department of Biotechnology, National Institute of Chemistry
Helena Gradišar: Department of Biotechnology, National Institute of Chemistry
Nino Bašić: Faculty of Mathematics and Physics, University of Ljubljana
Tomaž Pisanski: Faculty of Mathematics and Physics, University of Ljubljana
Jonathan P. K. Doye: Department of Chemistry, Physical and Theoretical Chemistry Laboratory, University of Oxford
Roman Jerala: Department of Biotechnology, National Institute of Chemistry

DOI: https://doi.org/10.1038/ncomms10803
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 8

Abstract

Read online

Driven by complementary base pairing, artificial single-chain DNA is capable of forming complex 3D architectures if an appropriate folding pathway can be realised. Here, the authors describe the design principles for rapidly folding structures, exemplified through fabrication of a nanosized square pyramid.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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