National trends in the prevalence and recurrence of anaphylaxis across all ages: The role of neighborhood deprivation and comorbidity (2002–2019)

Ju Hee Kim, MD; Eun Kyo Ha, MD; Jeewon Shin, MD; Nahyun Lee, BE; Bo Eun Han, BE; Man Yong Han, MD; Eun Lee, MD, PhD

World Allergy Organization Journal (Dec 2024)

National trends in the prevalence and recurrence of anaphylaxis across all ages: The role of neighborhood deprivation and comorbidity (2002–2019)

Ju Hee Kim, MD,
Eun Kyo Ha, MD,
Jeewon Shin, MD,
Nahyun Lee, BE,
Bo Eun Han, BE,
Man Yong Han, MD,
Eun Lee, MD, PhD

Affiliations

Ju Hee Kim, MD: Department of Pediatrics, Kyung Hee University Medical Center, Kyung Hee University School of Medicine, Seoul, South Korea; Corresponding author.
Eun Kyo Ha, MD: Department of Pediatrics, Kangnam Sacred Heart Hospital, Seoul, South Korea
Jeewon Shin, MD: Department of Pediatrics, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, South Korea
Nahyun Lee, BE: Department of Pediatrics, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, South Korea
Bo Eun Han, BE: Department of Pediatrics, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, South Korea
Man Yong Han, MD: Department of Pediatrics, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, South Korea; Corresponding author.
Eun Lee, MD, PhD: Department of Pediatrics, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, South Korea; Corresponding author.

Journal volume & issue: Vol. 17, no. 12
p. 101005

Abstract

Read online

Background: Understanding the trends of anaphylaxis and risk factors associated with its recurrence is essential for the effective management and prevention of this condition. Objective: This study aimed to analyze the prevalence trends of anaphylaxis and identify risk factors for recurrence, with a focus on the influence of neighborhood deprivation and comorbidities, across all age groups. Methods: We conducted a retrospective administrative cohort study on anaphylaxis utilizing the National Health Insurance-National Sample Cohort (NHIS-NSC) database in Korea (2002–2019). Anaphylaxis was defined with ICD-10 codes for the diagnosis combined with prescription codes. The Neighborhood Deprivation Index was used to identify the risk of recurrent anaphylaxis. Trends in the annual prevalence and recurrence of anaphylaxis were assessed through joinpoint regression and Cox proportional hazard models. Results: Out of the 1,137,861 individuals studied, 37,012 (3.25%) cases of anaphylaxis were identified. Among these, 5783 individuals (15.6%) experienced a recurrence, half of them experiencing it within the first year after the initial episode. The highest incidence of anaphylaxis was observed in children and adolescents, followed by middle-aged adults. A rapid increase in anaphylaxis cases was observed from 2002 to 2006 (Annual Percentage Change [APC], 33.2), followed by a more gradual increase until 2013 (APC, 12.8), and a stable trend from 2013 to 2019 (APC, 0.61). Males and adult age groups exhibited an increased risk of recurrence. Living in an area with neighborhood deprivation and the presence of comorbid conditions were associated with increased recurrence risk. Conclusions: The increasing prevalence of anaphylaxis and its association with certain risk factors calls for targeted intervention. Addressing neighborhood deprivation and comorbid conditions may aid in reducing the recurrence and overall burden of anaphylaxis.

Published in World Allergy Organization Journal

ISSN: 1939-4551 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy
Website: https://www.sciencedirect.com/journal/world-allergy-organization-journal

About the journal

Abstract

Keywords