PLoS ONE (Jan 2015)

Trypanosoma-Cruzi Cross-Reactive Antibodies Longitudinal Follow-Up: A Prospective Observational Study in Hematopoietic Stem Cell Transplantation.

  • Esber S Saba,
  • Lucie Gueyffier,
  • Marie-Laure Danjoy,
  • Philippe Vanhems,
  • Bruno Pozzetto,
  • Mohamad Sobh,
  • Hans Pottel,
  • Mauricette Michallet,
  • Maan A Zrein

DOI
https://doi.org/10.1371/journal.pone.0137240
Journal volume & issue
Vol. 10, no. 9
p. e0137240

Abstract

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Antibodies named TcCRA "Trypanosoma cruzi Cross Reactive Antibodies" were detected in 47% of blood donors from French population unexposed to the parasite. In order to evaluate the passive or active transmissibility of TcCRA and further characterize its role and etiology, we have conducted a study in a cohort of 47 patients who underwent allogeneic Hematopoietic Stem Cell Transplantations (allo-HSCT). Donors and recipients were tested for TcCRA prior to transplantation. Recipients were further tested during follow-up after transplantation. Demographical, clinical and biological data were collected. Our primary end-point was to assess the risk of TcCRA acquisition after transplantation. During this initial analysis, we observed no seroconversion in patients receiving cells from TcCRA negative donors (n = 23) but detected seroconversion in 4 out of 24 patients who received hematopoietic stem cells from positive donors. Here, we are discussing possible scenarios to explain TcCRA-immune status in recipient after transplantation.