Nature Communications (Jun 2021)
SARS-CoV-2 RBD trimer protein adjuvanted with Alum-3M-052 protects from SARS-CoV-2 infection and immune pathology in the lung
- Nanda Kishore Routhu,
- Narayanaiah Cheedarla,
- Venkata Satish Bollimpelli,
- Sailaja Gangadhara,
- Venkata Viswanadh Edara,
- Lilin Lai,
- Anusmita Sahoo,
- Ayalnesh Shiferaw,
- Tiffany M. Styles,
- Katharine Floyd,
- Stephanie Fischinger,
- Caroline Atyeo,
- Sally A. Shin,
- Sanjeev Gumber,
- Shannon Kirejczyk,
- Kenneth H. Dinnon,
- Pei-Yong Shi,
- Vineet D. Menachery,
- Mark Tomai,
- Christopher B. Fox,
- Galit Alter,
- Thomas H. Vanderford,
- Lisa Gralinski,
- Mehul S. Suthar,
- Rama Rao Amara
Affiliations
- Nanda Kishore Routhu
- Emory Vaccine Center, Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University
- Narayanaiah Cheedarla
- Emory Vaccine Center, Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University
- Venkata Satish Bollimpelli
- Emory Vaccine Center, Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University
- Sailaja Gangadhara
- Emory Vaccine Center, Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University
- Venkata Viswanadh Edara
- Emory Vaccine Center, Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University
- Lilin Lai
- Emory Vaccine Center, Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University
- Anusmita Sahoo
- Emory Vaccine Center, Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University
- Ayalnesh Shiferaw
- Emory Vaccine Center, Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University
- Tiffany M. Styles
- Emory Vaccine Center, Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University
- Katharine Floyd
- Emory Vaccine Center, Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University
- Stephanie Fischinger
- Ragon Institute of MGH, MIT and Harvard
- Caroline Atyeo
- Ragon Institute of MGH, MIT and Harvard
- Sally A. Shin
- Ragon Institute of MGH, MIT and Harvard
- Sanjeev Gumber
- Division of Pathology, Yerkes National Primate Research Center, Emory University
- Shannon Kirejczyk
- Division of Pathology, Yerkes National Primate Research Center, Emory University
- Kenneth H. Dinnon
- Department of Microbiology and Immunology, University of North Carolina
- Pei-Yong Shi
- Department of Biochemistry and Molecular Biology, The University of Texas Medical Branch
- Vineet D. Menachery
- Department of Microbiology and Immunology, The University of Texas Medical Branch
- Mark Tomai
- 3M Corporate Research Materials Laboratory
- Christopher B. Fox
- Infectious Disease Research Institute
- Galit Alter
- Ragon Institute of MGH, MIT and Harvard
- Thomas H. Vanderford
- Emory Vaccine Center, Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University
- Lisa Gralinski
- Department of Epidemiology, University of North Carolina
- Mehul S. Suthar
- Emory Vaccine Center, Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University
- Rama Rao Amara
- Emory Vaccine Center, Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University
- DOI
- https://doi.org/10.1038/s41467-021-23942-y
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 15
Abstract
Efficient vaccines for SARS-CoV-2 are needed. Here, the authors show that a trimeric form of the receptor-binding domain of SARS-CoV-2 spike adjuvanted with alum-3M-052 protects non-human primates from disease and inhibits infection.
