IFI16 and cGAS cooperate in the activation of STING during DNA sensing in human keratinocytes

Jessica F. Almine; Craig A. J. O’Hare; Gillian Dunphy; Ismar R. Haga; Rangeetha J. Naik; Abdelmadjid Atrih; Dympna J. Connolly; Jordan Taylor; Ian R. Kelsall; Andrew G. Bowie; Philippa M. Beard; Leonie Unterholzner

doi:10.1038/ncomms14392

Nature Communications (Feb 2017)

IFI16 and cGAS cooperate in the activation of STING during DNA sensing in human keratinocytes

Jessica F. Almine,
Craig A. J. O’Hare,
Gillian Dunphy,
Ismar R. Haga,
Rangeetha J. Naik,
Abdelmadjid Atrih,
Dympna J. Connolly,
Jordan Taylor,
Ian R. Kelsall,
Andrew G. Bowie,
Philippa M. Beard,
Leonie Unterholzner

Affiliations

Jessica F. Almine: Division of Cell Signalling and Immunology, School of Life Sciences, University of Dundee
Craig A. J. O’Hare: Division of Cell Signalling and Immunology, School of Life Sciences, University of Dundee
Gillian Dunphy: Division of Cell Signalling and Immunology, School of Life Sciences, University of Dundee
Ismar R. Haga: The Pirbright Institute
Rangeetha J. Naik: Division of Cell Signalling and Immunology, School of Life Sciences, University of Dundee
Abdelmadjid Atrih: Fingerprints Proteomics Facility, School of Life Sciences, University of Dundee
Dympna J. Connolly: School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin
Jordan Taylor: Division of Cell Signalling and Immunology, School of Life Sciences, University of Dundee
Ian R. Kelsall: Division of Cell Signalling and Immunology, School of Life Sciences, University of Dundee
Andrew G. Bowie: School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin
Philippa M. Beard: The Pirbright Institute
Leonie Unterholzner: Division of Cell Signalling and Immunology, School of Life Sciences, University of Dundee

DOI: https://doi.org/10.1038/ncomms14392
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 15

Abstract

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The role of IFI16 as a DNA sensor is highly controversial. With support from aNature Communications back-to-back publication from Jønsson et al., the authors here provide functional evidence that IFI16 is involved in DNA sensing via the cGAS-STING pathway in human keratinocytes.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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