Synthetic hydrogel nanoparticles for sepsis therapy

Hiroyuki Koide; Anna Okishima; Yu Hoshino; Yuri Kamon; Keiichi Yoshimatsu; Kazuhiro Saito; Ikumi Yamauchi; Saki Ariizumi; Yuqi Zhou; Ting-Hui Xiao; Keisuke Goda; Naoto Oku; Tomohiro Asai; Kenneth J. Shea

doi:10.1038/s41467-021-25847-2

Nature Communications (Sep 2021)

Synthetic hydrogel nanoparticles for sepsis therapy

Hiroyuki Koide,
Anna Okishima,
Yu Hoshino,
Yuri Kamon,
Keiichi Yoshimatsu,
Kazuhiro Saito,
Ikumi Yamauchi,
Saki Ariizumi,
Yuqi Zhou,
Ting-Hui Xiao,
Keisuke Goda,
Naoto Oku,
Tomohiro Asai,
Kenneth J. Shea

Affiliations

Hiroyuki Koide: Department of Medical Biochemistry, University of Shizuoka
Anna Okishima: Department of Medical Biochemistry, University of Shizuoka
Yu Hoshino: Department of Chemical Engineering, Kyushu University
Yuri Kamon: Department of Chemistry, University of California Irvine
Keiichi Yoshimatsu: Department of Chemistry, University of California Irvine
Kazuhiro Saito: Department of Medical Biochemistry, University of Shizuoka
Ikumi Yamauchi: Department of Medical Biochemistry, University of Shizuoka
Saki Ariizumi: Department of Medical Biochemistry, University of Shizuoka
Yuqi Zhou: Department of Chemistry, The University of Tokyo
Ting-Hui Xiao: Department of Chemistry, The University of Tokyo
Keisuke Goda: Department of Chemistry, The University of Tokyo
Naoto Oku: Department of Medical Biochemistry, University of Shizuoka
Tomohiro Asai: Department of Medical Biochemistry, University of Shizuoka
Kenneth J. Shea: Department of Chemistry, University of California Irvine

DOI: https://doi.org/10.1038/s41467-021-25847-2
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 14

Abstract

Read online

Sepsis caused by the release of inflammatory mediators into the blood is a life threatening disease. Here, the authors report on the development of hydrogel nanoparticles for the capture and neutralisation of histones, major inflammatory mediators, and demonstrate sepsis treatment in a murine model.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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