A Systems Biology Starter Kit for Arenaviruses

Abstract

Systems biology approaches in virology aim to integrate viral and host biological networks, and thus model the infection process. The growing availability of high-throughput “-omics” techniques and datasets, as well as the ever-increasing sophistication of in silico modeling tools, has resulted in a corresponding rise in the complexity of the analyses that can be performed. The present study seeks to review and organize published evidence regarding virus-host interactions for the arenaviruses, from alterations in the host proteome during infection, to reported protein-protein interactions. In this way, we hope to provide an overview of the interplay between arenaviruses and the host cell, and lay the foundations for complementing current arenavirus research with a systems-level approach.

Keywords

• Arenavirus
• interactome
• infectome
• virhostome
• biological networks
• systems biology
• Lassa fever virus
• Pichinde virus
• lymphocytic choriomeningitis virus
• Junin virus