Red Algal Bromophenols as Glucose 6-Phosphate Dehydrogenase Inhibitors

Abstract

Five bromophenols isolated from three Rhodomelaceae algae (Laurencia nipponica, Polysiphonia morrowii, Odonthalia corymbifera) showed inhibitory effects against glucose 6-phosphate dehydrogenase (G6PD). Among them, the symmetric bromophenol dimer (5) showed the highest inhibitory activity against G6PD.

Keywords

• bromophenol
• Rhodomelaceae
• pentose phosphate pathway (PPP)
• glucose 6-phosphate dehydrogenase
• inhibition