Canagliflozin combined with aerobic exercise protects against chronic heart failure in rats
Helin Sun,
Bingyu Du,
Hui Fu,
Zhaodi Yue,
Xueyin Wang,
Shaohong Yu,
Zhongwen Zhang
Affiliations
Helin Sun
Department of Endocrinology and Metabology, Shenzhen Research Institute of Shandong University, Shenzhen, China, Shandong Provincial Key Laboratory for Rheumatic Disease and Translational Medicine, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, China; Department of Endocrinology and Metabology, The Third Affiliated Hospital of Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China
Bingyu Du
Department of Endocrinology and Metabology, Shenzhen Research Institute of Shandong University, Shenzhen, China, Shandong Provincial Key Laboratory for Rheumatic Disease and Translational Medicine, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, China; Department of Endocrinology and Metabology, The Third Affiliated Hospital of Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China
Hui Fu
Cheeloo College of Medicine, Shandong University, Jinan, China
Zhaodi Yue
Teaching and Research Section of Internal Medicine, College of Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China; Department of rehabilitation medicine, The Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China
Xueyin Wang
Department of Endocrinology and Metabology, The Third Affiliated Hospital of Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China
Shaohong Yu
Teaching and Research Section of Internal Medicine, College of Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China; Department of rehabilitation medicine, The Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China; Corresponding author
Zhongwen Zhang
Department of Endocrinology and Metabology, Shenzhen Research Institute of Shandong University, Shenzhen, China, Shandong Provincial Key Laboratory for Rheumatic Disease and Translational Medicine, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, China; Department of Endocrinology and Metabology, The Third Affiliated Hospital of Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China; Corresponding author
Summary: To determine the efficacy and potential protective mechanism of canagliflozin combined with aerobic exercise in treating chronic heart failure (CHF). Isoproterenol was injected into rats to create CHF models. The rats were then subsequently divided into saline, canagliflozin (3 mg/kg/d), aerobic exercise training, and canagliflozin combined with aerobic exercise training. Compared to the CHF group, the canagliflozin combined with the aerobic exercise group had superior ventricular remodeling and cardiac function. In rats treated with canagliflozin combined with aerobic exercise, the expression of cytochrome P450 (CYP) 4A3, CYP4A8, COL1A1, COL3A1, and FN1 was reduced, while the expression of CYP26B1, ALDH1A2, and CYP1A1 increased significantly. Additionally, canagliflozin combined with aerobic exercise decreased the phosphorylation of AKT and ERK1/2. Canagliflozin combined with aerobic exercise has a positive effect on the development of CHF via the regulation of retinol metabolism and the AKT/ERK signaling pathway.
