Evaluation of Health-Related Quality of Life in Patients with Euthyroid Hashimoto’s Thyroiditis under Long-Term Levothyroxine Therapy: A Prospective Case-Control Study

Abstract

Objectives: To investigate quality of life using the SF-12 scale in euthyroid Hashimoto’s thyroiditis patients on levothyroxine therapy for at least three years. Methods: This prospective case–control study included 44 euthyroid Hashimoto’s thyroiditis patients and 44 matched controls, conducted at a university hospital’s endocrinology clinic from 6 November to 30 December 2023. Participants completed the SF-12 questionnaire; data were analyzed using Shapiro–Wilk, Student’s t-test, Mann–Whitney U, Yates chi-squared, and Spearman’s tests. Results: The study involved 88 participants (Hashimoto’s group: 35 females, 9 males; control group: 31 females, 13 males), with average ages of 49.50 and 47.43 years old, respectively. Significant differences were observed in TSH, T4 levels, and family history (p p p p > 0.05). Conclusions: Our study shows that effective control of hypothyroidism is not sufficient to reduce the negative effects of Hashimoto’s thyroiditis on patients’ health-related quality of life. Beyond the normalization of hormone levels, comprehensive therapeutic strategies targeting the autoimmune aspects of the disease are essential for the management of Hashimoto’s thyroiditis. This study provides a foundation for developing effective therapies that can enhance quality of life for patients with Hashimoto’s thyroiditis.

Keywords

• Hashimoto’s thyroiditis
• SF-12
• quality of life
• hypothyroidism